Results 181 to 190 of about 39,699,316 (287)

Implementation and sustainability of systems change for mental health promotion and substance misuse prevention: a qualitative study. [PDF]

BMC Health Serv Res
Burns A, Kampman H, Magee L, Blackburn J, Alton M, Pescosolido B.   +5 more
europepmc   +1 more source

A systems change framework for evaluating academic equity and inclusion in an Ecology and Evolution Graduate Program. [PDF]

Ecol Evol, 2020
Wallace KJ, York JM.
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

"It Made Me Change the Way I Do Business": Outcomes From Age-Friendly Community Initiatives as Systems Change. [PDF]

Gerontologist
Greenfield EA, Pope NE.
europepmc   +1 more source

Rapid health systems change: online medical consultations to fight COVID-19. [PDF]

Ann Transl Med, 2020
Wang H, Song P, Gu Y, Schroeder E, Jin C.   +4 more
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Lifestyles and their relative contribution to biological aging across multiple-organ systems: Change analysis from the China Multi-Ethnic Cohort study. [PDF]

Elife
Zhang Y, Tang D, Zhang N, Xiang Y, Hu Y, Qian W, Baima Y, Ding X, Wang Z, Yin J, Xiao X, Zhao X.   +11 more
europepmc   +1 more source

Association of the First 1,000 Days Systems-Change Intervention on Maternal Gestational Weight Gain. [PDF]

Obstet Gynecol, 2020
Blake-Lamb T, Boudreau AA, Matathia S, Perkins ME, Roche B, Cheng ER, Kotelchuck M, Shtasel D, Taveras EM.   +8 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

The Realist Approach to Social Policies (RASP) study: A study protocol for mixed-methods realist research combined with institutional action research, to reduce socioeconomic health inequalities through systems change

, 2023
Berkel Jv, de Bruijn E, Waardenburg M, Grouw Yl, Bennekom Ev, Horst Hvd, Tonnon S, Haggenburg-Mohammed M, Haveman A, Madern T, Knoef M, de Vet E.   +11 more
europepmc   +1 more source