Results 191 to 200 of about 39,699,316 (287)

Functions of innovation systems: A new approach for analysing technological change

, 2007
M. Hekkert, R. Suurs, S. Negro, S. Kuhlmann, R. Smits   +4 more
semanticscholar   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Workforce and systems change to treat adolescent substance use disorder within integrated pediatric primary care: A cluster-randomized stepped-wedge trial. [PDF]

Contemp Clin Trials
Hulvershorn LA, Aalsma M, Dellucci TV, Burns A, Marriott BR, Pescosolido B, Green HD, Saldana L, Chapman J, Monahan P, Wiehe SE, Miech EJ, Adams ZW.   +12 more
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Science for behavioral health systems change: evolving research-policy-public partnerships. [PDF]

Front Public Health
Southam-Gerow MA, Sale R, Robinson A, Sanborn V, Wu J, Boggs B, Riso A, Scalone M, Sandman A.   +8 more
europepmc   +1 more source

Climate Change and Global Food Systems: Potential Impacts on Food Security and Undernutrition.

Annual Review of Public Health, 2017
S. Myers, Matthew R. Smith, Sarah Guth, C. Golden, B. Vaitla, N. Mueller, A. Dangour, P. Huybers   +7 more
semanticscholar   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Trauma-informed systems change training has transcultural, transcontinental transformative healing power: An analysis of leaders in the United States and Angola, Africa. [PDF]

J Trauma Stress
Capuia D, da Cruz M, Masseca A, Marques E, Leite P, Mangus AR, Webb EK, Ravichandran C, Ressler KJ, Moreland-Capuia A.   +9 more
europepmc   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Flexible ureteroscopic treatment of kidney stones: How do the new laser systems change our concepts? [PDF]

Asian J Urol
Yu S, Liu L, Li Y, Zhou L, Chen J, Li H, Wang K.   +6 more
europepmc   +1 more source