Results 121 to 130 of about 4,654,755 (329)

Opportunities to apply systems engineering to healthcare interprofessional education. [PDF]

Front Med (Lausanne), 2023
Ferreira S, Phelps E, Abolmaali S, Reed G, Greilich P.   +4 more
europepmc   +1 more source

The systems engineering overview and process (from the Systems Engineering Management Guide, 1990) [PDF]

The past several decades have seen the rise of large, highly interactive systems that are on the forward edge of technology. As a result of this growth and the increased usage of digital systems (computers and software), the concept of systems ...

core   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Auto Mission Planning System Design for Imaging Satellites and Its Applications in Environmental Field

Polish Maritime Research, 2016
Satellite hardware has reached a level of development that enables imaging satellites to realize applications in the area of meteorology and environmental monitoring. As the requirements in terms of feasibility and the actual profit achieved by satellite
He Yongming, Wang Yuan, Chen Yingwu, Xing Lining   +3 more
doaj   +1 more source

Suggested criteria for evaluating systems engineering methodologies [PDF]

Systems engineering is the application of mathematical and scientific principles to practical ends in the life-cycle of a system. A methodology for systems engineering is a carefully developed, relatively complex procedure or process for applying these ...
Gates, Audrey, Gill, Tepper L., Paul, Arthur S.   +2 more
core   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Towards a Theory of Systems Engineering Processes: A Principal-Agent Model of a One-Shot, Shallow Process

, 2019
Systems engineering processes coordinate the effort of different individuals to generate a product satisfying certain requirements. As the involved engineers are self-interested agents, the goals at different levels of the systems engineering hierarchy ...
Bilionis, Ilias, Panchal, Jitesh, Safarkhani, Salar   +2 more
core  

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Artificial intelligence-driven systems engineering for next-generation plant-derived biopharmaceuticals. [PDF]

Front Plant Sci, 2023
Parthiban S, Vijeesh T, Gayathri T, Shanmugaraj B, Sharma A, Sathishkumar R.   +5 more
europepmc   +1 more source