Results 121 to 130 of about 4,318,020 (230)

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Phage-based delivery systems: engineering, applications, and challenges in nanomedicines. [PDF]

J Nanobiotechnology
Wang H, Yang Y, Xu Y, Chen Y, Zhang W, Liu T, Chen G, Wang K.   +7 more
europepmc   +1 more source

Wisconsin dairy farm worker perceptions and practices related to antibiotic use, resistance, and infection prevention using a systems engineering framework. [PDF]

PLoS One, 2021
Kates AE, Knobloch MJ, Konkel A, Young A, Steinberger A, Shutske J, Ruegg PL, Sethi AK, Goldberg T, Leite de Campos J, Suen G, Safdar N.   +11 more
europepmc   +1 more source

Stimulating the growth of small-scale industry [PDF]

, 1979
Georgia Institute of Technology. School of Industrial and Systems Engineering(Engineering Experiment Station), Wall, Nelson C.   +1 more
core  

Time, the final frontier

Molecular Oncology, EarlyView.
This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain, Michal Dibus, Omkar Joshi, Guillaume Jacquemet   +3 more
wiley   +1 more source

Retraction Note: Systems engineering of Escherichia coli for high-level glutarate production from glucose. [PDF]

Nat Commun
Zhang Z, Chu R, Wei W, Song W, Ye C, Chen X, Wu J, Liu L, Gao C.   +8 more
europepmc   +1 more source

Using Health Systems Engineering Approaches to Prepare for Tailoring of Implementation Interventions. [PDF]

J Gen Intern Med, 2021
Barnes GD, Acosta J, Kurlander JE, Sales AE.   +3 more
europepmc   +1 more source

Interplay of integrins and selectins in metastasis

Molecular Oncology, EarlyView.
Here we review the role of integrins and their interplay with selectins in metastasis. The efficacy of integrin‐targeted therapies may be reduced in tumors where metastasis relies heavily on selectins. In certain tumors, integrins and selectins exhibit a synergistic interaction during intraperitoneal dissemination.
Diana Maltseva, Ashot Nersisyan, Alexander Tonevitsky   +2 more
wiley   +1 more source

Advancing system of systems engineering using intangible value logic measurements from intellectual capital thinking approach. [PDF]

Heliyon
Zaghwan A, Amer Y, Efatmaneshnik M, Gunawan I.   +3 more
europepmc   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source