The Application of Karl Popper's Three Worlds Schema to Questions about Information in the Fields of Complexity, Cybernetics, and Informatics [PDF]
Journal of Systemics, Cybernetics and Informatics, 2015 More technically leaning disciplines such as informatics, complexity theory, and cybernetics often make simplifying assumptions about human beings and their causal/informational roles within larger techo-social systems. This paper employs the philosopher
Paul D. Nugent +2 more
doaj
The systems engineering overview and process (from the Systems Engineering Management Guide, 1990) [PDF]
The past several decades have seen the rise of large, highly interactive systems that are on the forward edge of technology. As a result of this growth and the increased usage of digital systems (computers and software), the concept of systems ...
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A New Robotics Educational System for Teaching Advanced Engineering Concepts to K-12 students [PDF]
, 2016 Fernando González, Janusz Zalewski
openalex +1 more source
YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma
Molecular Oncology, EarlyView.The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy +9 more
wiley +1 more source
History of visual systems in the Systems Engineering Simulator [PDF]
The Systems Engineering Simulator (SES) houses a variety of real-time computer generated visual systems. The earliest machine dates from the mid-1960's and is one of the first real-time graphics systems in the world.
Christianson, David C.
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Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Opportunities to apply systems engineering to healthcare interprofessional education. [PDF]
Front Med (Lausanne), 2023 Ferreira S +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
Suggested criteria for evaluating systems engineering methodologies [PDF]
Systems engineering is the application of mathematical and scientific principles to practical ends in the life-cycle of a system. A methodology for systems engineering is a carefully developed, relatively complex procedure or process for applying these ...
Gates, Audrey +2 more
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