Results 131 to 140 of about 1,597,830 (316)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

VISUAL MODELS OF SYSTEMS ENGINEERING OF ADDITIVE MANUFACTURING PROCESSES

Надежность и качество сложных систем
Background. The paper discusses methods for using visual systems engineering tools using the example of additive manufacturing processes. Materials and methods.
A.I. Vlasov, G.A. Volkov, K.V. Selivanov
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

International Conference on Industry, Engineering, and Management Systems 2015

, 2015
Published in SOAR: Shocker Open Access Repository by Wichita State University Libraries Technical Services, May 2022.The IEMS'15 conference committee: Nael Aly (Conference Co-Chair); Ahmad Elshennawy (Conference Co-Chair); Alfred Petrosky (Program Chair);
International Conference on Industry, Engineering, and Management Systems
core   +1 more source

Hybrid Space and Submarine Architecture to Ensure Information Security of Telecommunications (HEIST)

IEEE Access
Undersea communication cables (UCCs) are critical for global connectivity but remain vulnerable to physical and cyber threats. This paper presents insights from the NATO Science for Peace and Security Project: Hybrid Space and Submarine Architecture to ...
Nicolo Boschetti, Anurag Koyyada, Barrett Downs, William Rosenthal, Nathaniel Gordon, Hans Liwang, Alexander Marder, Johan Sigholm, Oskar Franberg, Jonas Kindgren, Thomas Frisk, Bjarni Mar Magnusson, Myriam Dunn Cavelty, Henric Johnson, Gregory Falco   +14 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

A systems engineering approach for global fleet station alternatives in the Gulf of Guinea [PDF]

, 2007
Includes supplementary materialThis Systems Engineering and Analysis Cohort 12 (SEA-12) report applies a systems engineering process to the largely qualitative Global Fleet Station (GFS) Concept, and its role in ensuring stability in the regions of the ...
Rummel, John P., Sullivan, Nagel B., SEA Cohort SEA-12, Ottersberg, Kathryn J., Montonye, John T., Crosby, R. Brian, Hansen, Christian A., Axiak, Frank C., Delaney, Jennifer M., Jomoto, Justin R., Tsui, Shipor, Hans, Brian E., McKenna, Matthew A.   +12 more
core  

A PREDICTIVE MAINTENANCE APPROACH FOR COMPLEX EQUIPMENT BASED ON A FAILURE MECHANISM PROPAGATION MODEL

International Journal of Prognostics and Health Management, 2019
The aim of this paper is to propose a comprehensive approach for the predictive maintenance of complex equipment. The approach relies on a physics of failure ( PoF ) model based on expert knowledge and data.
Olivier Blancke, Amélie Combette, Normand Amyot, Dragan Komljenovic, Mélanie Lévesque, Claude Hudon, Antoine Tahan, Noureddine Zerhouni   +7 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source