Results 121 to 130 of about 1,468,527 (267)

Symmetry Breaking in Chemical Systems: Engineering Complexity Through Self-Organization and Marangoni Flows. [PDF]

Adv Sci (Weinh)
Gore S, Paudyal BR, Rocha D, Ali M, Masmoudi N, Bae AJ, Diddens C, Lohse D, Steinbock O, Gholami A.   +9 more
europepmc   +1 more source

Sensor-Driven Human-Robot Synergy: A Systems Engineering Approach. [PDF]

Sensors (Basel), 2022
Tsolakis N, Gasteratos A.
europepmc   +1 more source

A MODEL-BASED SYSTEMS ENGINEERING STUDY OF AIRSHIPS FOR ANTI-SUBMARINE WARFARE

To support improved capability in Anti-Submarine Warfare (ASW) defense of the U.S. west coast, this research project investigates the technical and cost feasibility of developing an ASW airship.
Cromwell, Brittney L., Handrigan, John J., IV, Blanchard, Monica L., Santos, Delaney R.   +3 more
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

A Systematic Review of Advanced Drug Delivery Systems: Engineering Strategies, Barrier Penetration, and Clinical Progress (2016-April 2025). [PDF]

Pharmaceutics
Uzakova AB, Yergaliyeva EM, Yerlanuly A, Mukatayeva ZS.   +3 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Entangled Autopoiesis: Reframing Psychotherapy and Neuroscience Through Cognitive Science and Systems Engineering. [PDF]

Brain Sci
Rad D, Maier M, Triff Z, Marcu R.
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Embedding Systems Engineering Leadership in Learning Health Systems: The Case for a Chief Systems Engineer in Every Hospital. [PDF]

Learn Health Syst
Xames MD.
europepmc   +1 more source

Teaching systems engineering to undergraduates; Experiences and considerations

, 2013
Undergraduates need a teaching style that fits their limited experience. Especially in systems engineering this is an issue, since systems engineering connects to so many different stakeholders with so many different concerns while the students have ...
Scott, P., Johnson, K., Adcock, R., Sobkiw, W., LeBlanc, R., Muller, Gerrit, Bonnema, Gerrit Maarten   +6 more
core