Results 171 to 180 of about 25,134,561 (338)

StreamLink: Large-Language-Model Driven Distributed Data Engineering System [PDF]

D. L. Feng, Dongming Mei, Huanmi Tan, Lei Ren, X. C. Lou, Zhangxi Tan   +5 more
openalex   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Current Situation and Development Trend of Electrical Automation Engineering Control System

, 2020
Guokun Xie
openalex   +1 more source

Transforming systems engineering through digital engineering

, 2019
Mary A. Bone, M. Blackburn, D. Rhodes, David N Cohen, J. Guerrero   +4 more
semanticscholar   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

A systems engineering approach to alarm management on pediatric medical-surgical units. [PDF]

J Hosp Med
Ruppel H, Luo B, Rasooly IR, McNamara M, McLoone M, Kern-Goldberger A, Ferro DF, Albanowski K, Brent C, Cieplinski JA, Irizarry J, Rottenberg S, Hehir D, Stinson HR, Makeneni S, Hamershock RA, Won J, Bonafide CP.   +17 more
europepmc   +1 more source

SafeSysE: A Safety Analysis Integration in Systems Engineering Approach

IEEE Systems Journal, 2018
F. Mhenni, Nga Nguyen, J. Choley
semanticscholar   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

New horizons in systems engineering and thinking to improve health and social care for older people. [PDF]

Age Ageing
Aujla N, Tooman T, Arakelyan S, Kerby T, Hartley L, O'Donnell A, Guthrie B, Underwood I, Jacko JA, Anand A.   +9 more
europepmc   +1 more source

Using Health Systems Engineering Approaches to Prepare for Tailoring of Implementation Interventions. [PDF]

J Gen Intern Med, 2021
Barnes GD, Acosta J, Kurlander JE, Sales AE.   +3 more
europepmc   +1 more source