Results 171 to 180 of about 4,929,681 (330)

Synergetic approachto simulation of physical wear of engineering technical systems

, 2015
Andrey Mikhaylovich Kirillov, Mikhail Aleksandrovich Zav’yalov   +1 more
openalex   +1 more source

The application of systems engineering principles on organisational level [PDF]

, 2005
Siebert Benade
openalex   +1 more source

Portable CRISPR-Cas9 ^N System for Flexible Genome Engineering in Lactobacillus acidophilus, Lactobacillus gasseri, and Lactobacillus paracasei

, 2021
Yong Jun Goh, Rodolphe Barrangou
openalex   +2 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

A Systematic Review of Advanced Drug Delivery Systems: Engineering Strategies, Barrier Penetration, and Clinical Progress (2016-April 2025). [PDF]

Pharmaceutics
Uzakova AB, Yergaliyeva EM, Yerlanuly A, Mukatayeva ZS.   +3 more
europepmc   +1 more source

Systems engineering-based framework of process risks in perioperative medication delivery. [PDF]

Br J Anaesth, 2022
Coppola SM, Neyens DM, Catchpole K, Gurses AP, Osei P, Biro JM, Alfred M, Rucks M, Tobin CD, Jaruzal C, Abernathy JH, Operating Room System based Medication Administration error Reduction Team (OR SMART) Research Group.   +11 more
europepmc   +1 more source

Two-step residual-error based approach for anomaly detection in engineering systems using variational autoencoders

, 2022
Ana González, Ignacio Díaz, Abel A. Cuadrado, Diego García-Pérez, Daniel Pérez   +4 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Embedding Systems Engineering Leadership in Learning Health Systems: The Case for a Chief Systems Engineer in Every Hospital. [PDF]

Learn Health Syst
Xames MD.
europepmc   +1 more source

"We should be resourcing their liberation:" a qualitative formative study to guide introduction of a systems engineering intervention at a King County, WA juvenile detention center clinic. [PDF]

BMC Health Serv Res, 2023
Borges M, Schipper L, Gonzalez G, Goode S, Hersh D, Pham DQ, Kaplan B, Ronen K, Sherr K, Gimbel S.   +9 more
europepmc   +1 more source