Results 211 to 220 of about 4,929,681 (330)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

New horizons in systems engineering and thinking to improve health and social care for older people. [PDF]

Age Ageing
Aujla N, Tooman T, Arakelyan S, Kerby T, Hartley L, O'Donnell A, Guthrie B, Underwood I, Jacko JA, Anand A.   +9 more
europepmc   +1 more source

Using Health Systems Engineering Approaches to Prepare for Tailoring of Implementation Interventions. [PDF]

J Gen Intern Med, 2021
Barnes GD, Acosta J, Kurlander JE, Sales AE.   +3 more
europepmc   +1 more source

Floquet engineering of classical systems [PDF]

, 2018
Sho Higashikawa, Hiroyuki Fujita, Masahiro Sato   +2 more
openalex   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Phage-based delivery systems: engineering, applications, and challenges in nanomedicines. [PDF]

J Nanobiotechnology
Wang H, Yang Y, Xu Y, Chen Y, Zhang W, Liu T, Chen G, Wang K.   +7 more
europepmc   +1 more source

A Cognitive Systems Engineering Approach Using Unsupervised Fuzzy C-Means Technique, Exploratory Factor Analysis and Network Analysis-A Preliminary Statistical Investigation of the Bean Counter Profiling Scale Robustness. [PDF]

Int J Environ Res Public Health, 2022
Rad D, Cuc LD, Lile R, Balas VE, Barna C, Pantea MF, Bâtcă-Dumitru GC, Szentesi SG, Rad G.   +8 more
europepmc   +1 more source

Engineering Magnetization with Photons: Nanoscale Advances in the Inverse Faraday Effect for Metallic and Plasmonic Systems [PDF]

Chantal Hareau, Xingyu Yang, Maria del Henar Rojo Sanz, Matthew Sheldon, Mathieu Mivelle   +4 more
openalex   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Retraction Note: Systems engineering of Escherichia coli for high-level glutarate production from glucose. [PDF]

Nat Commun
Zhang Z, Chu R, Wei W, Song W, Ye C, Chen X, Wu J, Liu L, Gao C.   +8 more
europepmc   +1 more source