Results 191 to 200 of about 1,162,431 (318)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Enhancing Surveillance Systems: Integration of Object, Behavior, and Space Information in Captions for Advanced Risk Assessment. [PDF]

Sensors (Basel)
Jeon M, Ko J, Cheoi K.
europepmc   +1 more source

ONDEX - a data integration framework for the life sciences

, 2011
Taubert J. ONDEX - a data integration framework for the life sciences. Bielefeld (Germany): Bielefeld University; 2011.Over the last decade biological research has changed completely.
Taubert, Jan, Taubert, J.
core  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

An executive-functions-based reading training enhances sensory-motor systems integration during reading fluency in children with dyslexia. [PDF]

Cereb Cortex
Farah R, Dworetsky A, Coalson RS, Petersen SE, Schlaggar BL, Rosch KS, Horowitz-Kraus T.   +6 more
europepmc   +1 more source

Managing the Hydra in integration: developing an integrated assessment tool for agricultural systems

, 2009
Keywords: modelling, bio-economic, farm, simulation, ontology, knowledge management, Europe, agricultural management, database, scenario Ex-ante assessment through science-based methods can provide insight into the impacts of potential policy measures ...
Janssen, S.J.C.
core  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Age-Friendly Health Systems Integration into Rural Primary Care Clinics: A Journey of One Geriatric Workforce Enhancement Program. [PDF]

Inquiry
Tobey-Moore L, Scalzo K, Massey S, McAtee R.   +3 more
europepmc   +1 more source

Integration in noncommutative systems [PDF]

Transactions of the American Mathematical Society, 1950
openaire   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source