Results 171 to 180 of about 1,162,431 (318)

Integrating Large Language Models into Traffic Systems: Integration Levels, Capability Boundaries, and an Information-Theoretic Perspective. [PDF]

Entropy (Basel)
Tu W, Li J, Xiao F, Wang X, Lu Y.
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Techno-economic analysis for a 100% renewable hybrid energy systems integration in a research facility in Morocco. [PDF]

iScience
Choukri NE, Touili S, Azzaoui A, Alami Merrouni A.   +3 more
europepmc   +1 more source

Smart Cell Culture Systems: Integration of Sensors and Actuators into Microphysiological Systems. [PDF]

ACS Chem Biol, 2018
Modena MM, Chawla K, Misun PM, Hierlemann A.   +3 more
europepmc   +1 more source

Integrated Information Systems [PDF]

Yearbook of Medical Informatics, 1993
openaire   +2 more sources

A Research Roadmap for Test Design in Automated Integration Testing of Vehicular Systems [Elektronisk resurs]

, 2016
An increasing share of the innovations emerging in the vehicular industry are implemented in software. Consequently, vehicular electrical systems are becoming more and more complex with an increasing number of functions, computational nodes and complex ...
Gustafsson, Thomas,, Sundmark, Daniel,, Kobetski, Avenir,, Flemström, Daniel,   +3 more
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Potential benefits and human systems integration of parastronauts with bilateral vestibulopathy for a space mission. [PDF]

Front Neurol
Ramsburg CF, Wood SJ, Lackner JR, Moynihan S, Reschke MF, Denise P, Clément G.   +6 more
europepmc   +1 more source

Indicators and Measurement Tools for Health Systems Integration: A Knowledge Synthesis. [PDF]

Int J Integr Care, 2017
Suter E, Oelke ND, da Silva Lima MAD, Stiphout M, Janke R, Witt RR, Van Vliet-Brown C, Schill K, Rostami M, Hepp S, Birney A, Al-Roubaiai F, Marques GQ.   +12 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source