Results 151 to 160 of about 12,378,837 (298)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

From Devices to Systems: Integration Strategies for Micro-Supercapacitors in Microsystems. [PDF]

Adv Sci (Weinh)
Liu Z, Li G, Wang K.
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Estratégias de integração entre atenção primária à saúde e atenção especializada: paralelos entre Brasil e Espanha

Saúde em Debate
Este artigo analisa estratégias desenvolvidas por Brasil e Espanha para integrar Atenção Primária à Saúde e Especializada. Entre as iniciativas comuns, observa-se: papel de filtro exercido pelo médico de família, territorialização dos serviços de saúde ...
Patty Fidelis de Almeida, Juan Gérvas, José-Manuel Freire, Lígia Giovanella   +3 more
doaj  

Self-Sustaining Sensing Systems: Integration Strategies and Signal-Power Matching in Energy-Harvesting Electronics. [PDF]

Adv Sci (Weinh)
Park T, Park KY, Choi Y, Shin DM, Yoon HJ, Yoo H.   +5 more
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Polio transition in the African Region: progress, challenges and prospects for health systems integration. [PDF]

BMC Infect Dis
Nomhwange T, Ainan S, Nduotabe M, Adamu U, Chinwike O, Adejoh K, Adamu S, Kamugisha C, Johnson T, Manengu C, Mohamed G.   +10 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Beyond Compliance: Identifying High-Performance Models and Critical Success Factors for Integrated Management System Effectiveness (A Systematic Review)

Ianna Journal of Interdisciplinary Studies
Background: Organisations' interest in integrating management systems has emerged as a key strategy for improving organisational performance. Finding a model that fits the organisation's needs and optimises activities with the greatest possible benefit ...
Jesús Enrique Osorio Romero, Dina Luz Castro Páez, Braian López Ossa, Mabel Ibarra Luna   +3 more
doaj  

Integrating Large Language Models into Traffic Systems: Integration Levels, Capability Boundaries, and an Information-Theoretic Perspective. [PDF]

Entropy (Basel)
Tu W, Li J, Xiao F, Wang X, Lu Y.
europepmc   +1 more source