Results 131 to 140 of about 4,023,339 (305)
Requirements analysis in the implementation of integrated PLM, ERP and CAD systems [PDF]
, 2013 Product Lifecycle Management (PLM) system implementation is a major investment when the technology is used in manufacturing companies. This paper provides an analysis of the requirements for the integration of PLM systems with Enterprise Resource ...
James, Gao +3 more
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Opportunistic plant observations reveal spatial and temporal gradients in phenology
npj BiodiversityOpportunistic plant records provide a rapidly growing source of spatiotemporal plant observation data. Here, we used such data to explore the question whether they can be used to detect changes in species phenologies.
Michael Rzanny +4 more
doaj +1 more source
Multi Channel Architecture Model Based on Service Oriented Integration [PDF]
The volume of data and numerous applications developed within a company can often generate a redundancy difficult to control. In the same time, the homogeneous or heterogeneous management systems of the companies become overcharged for obtaining useful ...
Anda VELICANU, Davian POPESCU, Ion LUNGU
core
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
The Level of Information Systems Integration in Romania [PDF]
Integration is an activity that unites people, equipments, programs but also managerial practices and helps a company to put its knowledge into good use.
Iuliana BOTHA, Vlad DIACONITA
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source