Results 111 to 120 of about 12,378,837 (298)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Heterogeneous Autonomous Robotic System in Viticulture and Mariculture: Vehicles Development and Systems Integration. [PDF]

Sensors (Basel), 2022
Kapetanović N, Goričanec J, Vatavuk I, Hrabar I, Stuhne D, Vasiljević G, Kovačić Z, Mišković N, Antolović N, Anić M, Kozina B.   +10 more
europepmc   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Need for a systems integration methodology for effective implementation of simulation-based training. [PDF]

Ann Thorac Med, 2021
Johnson PA, Johnson JC.
europepmc   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Smart Systems Integration, SSI 2025. Proceedings

The Smart Systems Integration (SSI) Conference covers topics along the entire value chain of smart systems. The conference addressed recent developments in the field of Smart Systems Integration - especially the integration of different functionalities ...

core   +1 more source

Air-Aware Port–City–Logistics Systems: An Integrated Governance Framework for Air Quality, Resilience, and Sustainable Urban Development

Air
Air pollution in urban and coastal regions is increasingly shaped by interactions among port operations, freight logistics, urban mobility systems, spatial development patterns, and governance arrangements.
Maria Tsami
doaj   +1 more source

The complexity of scaling up an mHealth intervention: the case of SMS for Life in Tanzania from a health systems integration perspective. [PDF]

BMC Health Serv Res, 2021
Sant Fruchtman C, Mbuyita S, Mwanyika-Sando M, Braun M, de Savigny D, Cobos Muñoz D.   +5 more
europepmc   +1 more source