Results 91 to 100 of about 1,162,431 (318)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Certified Ejection Seat Weight Ranges and their Effects on Personnel Selection [PDF]
, 2014 Human Systems Integration (HSI) CapstoneCurrent ejection seat certified aircrew weight ranges (136 to 213 lbs.), such as for the F/A-18, prohibited over one third (38%) of women and (8%) of men from accessing the naval aviation strike pipeline (carrier ...
Jones, Thomas C.
core
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Integration between Primary Health Care and Emergency Services in Brazil: Barriers and Facilitators
International Journal of Integrated Care, 2018 Introduction: Characteristics of primary health care and emergency services may hamper their integration and, therefore, reduce the quality of care and the effectiveness of health systems.
Liza Yurie Teruya Uchimura +2 more
doaj +1 more source
Characterising Enterprise Application Integration Solutions as Discrete-Event Systems
, 2015 It is not difficult to find an enterprise which has a software ecosystem composed of applications that were built using different technologies, data models, operating systems, and most often were not designed to exchange data and share functionalities ...
Fabricia Roos-Frantz, Fabricia +5 more
core +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Tailoring MIL-STD-1472G: developing a system–level MANPRINT requirements document for contract use in the acquisition of military ground combat vehicles [PDF]
, 2013 This document has been created to initiate an artifact which can be further developed into a hard contract requirements document that will mandate human design requirements as critical and requiring accountability on programs.
Swain, Deborah L.
core
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
More than rapid identification—Free plant identification apps can also be highly accurate
People and NatureHart et al. (2023) conducted a study to evaluate the accuracy of five plant identification apps based on snapshot images as used in practice by field ecologists. Their results revealed varying accuracies per app, ranging from 86.9% to 46.4%.
Michael Rzanny +6 more
doaj +1 more source