Results 101 to 110 of about 4,023,339 (305)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Editorial: Frontiers in dental medicine: highlights in systems integration 2021/22. [PDF]
Front Dent Med, 2023 Chu E, Nociti FH.
europepmc +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Production, 2008 Este trabalho apresenta uma metodologia de projeto aplicada a sistemas automatizados e integrados de manufatura. A metodologia consiste em um desenvolvimento cíclico de três etapas - modelagem, síntese e implementação - até o atendimento da aplicação ...
Marco Antonio Busetti de Paula +1 more
doaj +1 more source
Semantic integration process of business components to support information system designers
, 2013 The present work is inscribed within the intersection of two scientific thematic: the engineering by reuse of components and ontologies alignment. The integration of Business Components (BC) is a research problem that has been identified in the field of ...
Elasri, Hicham, Sekkaki, Abderrahim
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Journal of Public Health Research, 2016 Health informatics has a major role to play in optimising the management and use of data, information and knowledge in health systems. As health systems undergo digital transformation, it is important to consider informatics approaches not only to ...
Kathleen Gray
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Real-time motor rotation frequency detection with event-based visual and spike-based auditory AER sensory integration for FPGA [PDF]
, 2015 Multisensory integration is commonly used in various robotic areas to collect more environmental information using different and complementary types of sensors. Neuromorphic engineers mimics biological systems behavior to improve systems performance
Cerezuela Escudero, Elena +5 more
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