Results 101 to 110 of about 12,378,837 (298)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Production, 2008 Este trabalho apresenta uma metodologia de projeto aplicada a sistemas automatizados e integrados de manufatura. A metodologia consiste em um desenvolvimento cíclico de três etapas - modelagem, síntese e implementação - até o atendimento da aplicação ...
Marco Antonio Busetti de Paula +1 more
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Opportunistic plant observations reveal spatial and temporal gradients in phenology
npj BiodiversityOpportunistic plant records provide a rapidly growing source of spatiotemporal plant observation data. Here, we used such data to explore the question whether they can be used to detect changes in species phenologies.
Michael Rzanny +4 more
doaj +1 more source
Journal of Public Health Research, 2016 Health informatics has a major role to play in optimising the management and use of data, information and knowledge in health systems. As health systems undergo digital transformation, it is important to consider informatics approaches not only to ...
Kathleen Gray
doaj +1 more source
Editorial: Frontiers in dental medicine: highlights in systems integration 2021/22. [PDF]
Front Dent Med, 2023 Chu E, Nociti FH.
europepmc +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
An evaluation of hospital Information Systems integration approaches [PDF]
, 2012 Healthcare organisations aim to provide high-quality, cost-effective healthcare delivery; to do this they must manage a large amounts of information. A fundamental concern in health management is the integration of health information across distributed ...
Toohey, D. +5 more
core +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Integration as a two-way process in the EU? Assessing the Relationship between the European Integration Fund and the Common Basic Principles on Integration. CEPS Paperbacks, July 2011 [PDF]
, 2011 This report examines the nature, the limits and potential of the principle of integration as a two-way process of mutual accommodation between migrants and the receiving societies.
Atger, Anais Faure, Carrera, Sergio
core