Results 121 to 130 of about 12,378,837 (298)
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Smart Systems Integration, SSI 2024. Proceedings
The Smart Systems Integration (SSI) Conference covers topics along the entire value chain of smart systems. The conference addressed recent developments in the field of Smart Systems Integration - especially the integration of different functionalities ...
core +1 more source
Becoming a MANPRINT Team Player [PDF]
, 2014 Human Systems Integration (HSI) CapstoneMANPRINT efforts have the greatest impact when initiated early in the acquisition process, when changes to a system can be made most easily.
Sapp, Jared J.
core +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Smart Systems Integration, SSI 2023. Proceedings
The Smart Systems Integration (SSI) Conference covers topics along the entire value chain of smart systems. The conference addressed recent developments in the field of Smart Systems Integration - especially the integration of different functionalities,
core +1 more source
Applied SciencesTo address the challenge of dispatching emergency resources for community residents under extreme ice disaster, this paper proposes an emergency resource dispatch strategy based on pre-disaster prediction and dynamic scheduling.
Runyi Pi +5 more
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Certified Ejection Seat Weight Ranges and their Effects on Personnel Selection [PDF]
, 2014 Human Systems Integration (HSI) CapstoneCurrent ejection seat certified aircrew weight ranges (136 to 213 lbs.), such as for the F/A-18, prohibited over one third (38%) of women and (8%) of men from accessing the naval aviation strike pipeline (carrier ...
Jones, Thomas C.
core +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source