Results 161 to 170 of about 1,162,431 (318)
A model of systems integration to facilitate intelligent transportation systems deployment
The FAST-TRAC (Faster and Safer Travel through Traffic Routing and Advanced Controls) Intelligent Transportation Systems (ITS) Field Test in Oakland County, an urbanized county in metropolitan Detroit, represents a large and successful systems ...
LeBay, Mark R. +2 more
core
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Nordic pension systems in a European differentiated integration perspective
Pension systems remain a national competence in the EU member states and are undergoing reforms in all European countries. There are some tendencies to integration of the systems, but large differences remain.
Wadensjö, Eskil,, Pintsch, Anne
core +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Saúde em DebateEste artigo analisa estratégias desenvolvidas por Brasil e Espanha para integrar Atenção Primária à Saúde e Especializada. Entre as iniciativas comuns, observa-se: papel de filtro exercido pelo médico de família, territorialização dos serviços de saúde ...
Patty Fidelis de Almeida +3 more
doaj
Information system integration: a review of literature and a case analysis [PDF]
The article aims at providing an explanation on information systems integration. It is an account that is part of an on-going research. In the first part of the article, the researchers present the literature review. The findings show the characteristics
Haghshenas, Hanif +4 more
core
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Ianna Journal of Interdisciplinary StudiesBackground: Organisations' interest in integrating management systems has emerged as a key strategy for improving organisational performance. Finding a model that fits the organisation's needs and optimises activities with the greatest possible benefit ...
Jesús Enrique Osorio Romero +3 more
doaj