Results 61 to 70 of about 1,162,431 (318)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
HSI Framework for Organizations [PDF]
, 2014 Human Systems Integration (HSI) CapstoneIn the United States Air Force (USAF), a system is generally thought of in terms of technology; but there are other types of systems supporting our warfighters.
Shihady, Jessica L.
core
Integration of decision support systems to improve decision support performance
, 2010 Decision support system (DSS) is a well-established research and development area. Traditional isolated, stand-alone DSS has been recently facing new challenges.
Whitfield, R.I. +7 more
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Framework for Assessing Impact of Wave-Powered Desalination on Resilience of Coastal Communities
Journal of Marine Science and EngineeringCoastal communities face unique challenges in maintaining continuous service from critical infrastructure. This research advances capabilities for evaluating the impact of using wave energy to desalinate water on the resilience of coastal communities ...
Kelley Ruehl +3 more
doaj +1 more source
, 2022 S.201-206In the field of high volume production, e.g. in the automotive industry, there is a strong demand for process control based on wireless sensor nodes.
Reinhardt, D. +4 more
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Smart Systems Integration, SSI 2023. Proceedings
The Smart Systems Integration (SSI) Conference covers topics along the entire value chain of smart systems. The conference addressed recent developments in the field of Smart Systems Integration - especially the integration of different functionalities,
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
npj Climate and Atmospheric ScienceRecent advancements in artificial intelligence (AI) numerical weather prediction (NWP) have transformed atmospheric modeling. AI NWP models outperform state-of-the-art conventional NWP models like the European Center for Medium Range Weather Forecasting ...
John S. Schreck +11 more
doaj +1 more source