Results 111 to 120 of about 2,134 (208)

Analytical study of fractional solitons in three dimensional nonlinear evolution equation within fluid environments. [PDF]

Sci Rep
Ramadan ME, Ahmed HM, Khalifa AS, Ahmed KK.   +3 more
europepmc   +1 more source

Autophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSC‐Derived Cortical Organoids

Advanced Science, EarlyView.
A new cerebrocortical organoid model using isogenic hiPSCs with familial Alzheimer's mutations recapitulates key AD features, including amyloid‐beta and phospho‐Tau aggregation, neuronal hyperexcitability, and synapse loss. Single‐cell RNA‐seq reveals aberrant pathways in excitatory and inhibitory neurons.
Sergio R. Labra, Jadon Compher, Akhil Prabhavalkar, Mireya Almaraz, Claudia Cedeño Kwong, Christine Baal, Maria Talantova, Nima Dolatabadi, Julian Piña‐Sanz, Yubo Wang, Leonard Yoon, Swagata Ghatak, Zi Gao, Yuting Zhang, Dorit Trudler, Lynee Massey, Wei Lin, Anthony Balistreri, Michael Bula, Nicholas J. Schork, Tony S. Mondala, Steven R. Head, Jeffery W. Kelly, Stuart A. Lipton   +23 more
wiley   +1 more source

Edge-Enabled Hybrid Encryption Framework for Secure Health Information Exchange in IoT-Based Smart Healthcare Systems. [PDF]

Sensors (Basel)
Ghani NA, Bagustari BA, Ahmad M, Tolle H, Kurnianingtyas D.   +4 more
europepmc   +1 more source

Aberrant Splicing Signatures Underpin Oligodendrocyte Damage in ALS and Neuron Loss in FTD

Advanced Science, EarlyView.
Integrating bulk and single‐nucleus RNA‐seq from ALS and FTD patients, we revealed distinct cellular dysfunctions, with severe oligodendrocyte damage in ALS and pronounced neuron loss in FTD. We identified cell‐type‐specific aberrant splicing events as potential biomarkers with robust classification performance, some of which produce de novo peptides ...
Chen Du, Yinming Li, Rong Wu, Yufei Shen, Jiayi Yang, Xuan Xiao, Yu Zhou   +6 more
wiley   +1 more source

Study of phase separation process in multi-component mixtures using analytical methods and decomposition variational iteration method for the fourth-order Cahn-Hilliard equation. [PDF]

Sci Rep
Luo J, Manafian J, Aghazadeh A, Ilhan OA, Eslami B, Fattah AA, Mahmoud KH, Aghdaei MF.   +7 more
europepmc   +1 more source

NuSAP Safeguards Centriole Integrity to Mediate CEP57‐CEP152 Torus Recruitment for Proper Engagement

Advanced Science, EarlyView.
This study reveals a novel role for the microtubule stabilizer NuSAP at centrioles. NuSAP depletion destabilizes the centriole's tubulin structure, causing premature disengagement, PCM defects, and mis‐localization of the CEP57‐CEP63‐CEP152 complex. By reinforcing centriole architecture, NuSAP enables early CEP57 loading and initiates a newly proposed ...
Shiyu Zhang, Zemin Jiang, Qiaoyun Yang, Hong Zheng, Minghao Wang, Chennianci Zhu, Lih‐Wen Deng, Karen Carmelina Crasta, Yih‐Cherng Liou   +8 more
wiley   +1 more source

Structural identifiability of linear-in-parameter parabolic PDEs through auxiliary elliptic operators. [PDF]

J Math Biol
Salmaniw Y, Browning AP.
europepmc   +1 more source

Helix Alignment, Chevrons, and Edge Dislocations in Twist‐Bend Ferroelectric Nematics

Advanced Science, EarlyView.
The recently discovered twist‐bend ferroelectric nematic (NTBF) is the new member of the multiferroic family, representing a fluid with an oblique helicoidal (heliconical) periodic structure of spontaneous electric polarization. The work presents a thorough exploration of the material properties of this phase, how the periodic modulation of ...
Bijaya Basnet, Priyanka Kumari, Sathyanarayana Paladugu, Damian Pociecha, Jakub Karcz, Przemysław Kula, Nataša Vaupotič, Ewa Górecka, Oleg D Lavrentovich   +8 more
wiley   +1 more source

Exact wave structures with stochastic effects in birefringent optical fibers modeled by cubic-quintic-septic nonlinear Schrödinger equation. [PDF]

Sci Rep
Rabie WB, Almotairi ES, Ahmed HM, Ali MH.   +3 more
europepmc   +1 more source

The Interplay of Magnetic Order with the Electronic Scattering and Crystal‐Field Effects in a Metallic Ferromagnet

Advanced Science, EarlyView.
The interplay between magnetic ordering and crystal electric field (CEF) excitations plays a pivotal role in defining the low‐energy electrodynamics of quantum materials. By probing the temperature‐dependent THz conductivity in a rare‐earth‐based metallic ferromagnet, we uncover a microscopic connection between localized and itinerant electrons ...
Payel Shee, Tanaya Halder, Chia‐Jung Yang, Nainish Tickoo, Ratiranjan Samal, Ruta Kulkarni, Shishir K. Pandey, Vikas Kashid, Ashis K. Nandy, Arumugam Thamizhavel, Anamitra Mukherjee, Shovon Pal   +11 more
wiley   +1 more source