Results 71 to 80 of about 1,238,424 (312)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

A rapid assessment of co-benefits and trade-offs among Sustainable Development Goals

Marine Policy, 2017
Achieving the United Nations’ 17 Sustainable Development Goals (SDGs) results in many ecological, social, and economic consequences that are inter-related.
G. Singh, A. Cisneros‐Montemayor, W. Swartz, William W. L. Cheung, J. Guy, T. Kenny, Chris McOwen, R. Asch, J. Geffert, C. Wabnitz, R. Sumaila, Quentin Hanich, Yoshitaka Ota   +12 more
semanticscholar   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

ReCovNet: Reinforcement learning with covering information for solving maximal coverage billboards location problem

International Journal of Applied Earth Observations and Geoinformation
Maximizing billboard coverage with limited resources and different objective goals plays a vital role in social activities. The Maximal Coverage Billboard Location Problem (MCBLP) is complex, especially for multi-objective functions.
Yang Zhong, Shaohua Wang, Haojian Liang, Zhenbo Wang, Xueyan Zhang, Xi Chen, Cheng Su   +6 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

The Computational Challenges of Pursuing Multiple Goals: Network Structure of Goal Systems Predicts Human Performance

, 2018
Extant psychological theories attribute people’s failure to achieve their goals primarily to failures of self-control, insufficient motivation, or lacking skills. We develop a complementary theory specifying conditions under which the computational complexity of making the right decisions becomes prohibitive of goal achievement regardless of skill or ...
Daniel Reichman, Falk Lieder, David Bourgin, Nimrod Talmon, Thomas L. Griffiths   +4 more
openaire   +3 more sources

A Holistic approach to corporate sustainability assessment: Incorporating sustainable development goals into sustainable manufacturing performance evaluation

Journal of manufacturing systems, 2019
Corporate Sustainability Assessment (CSA) in manufacturing is a framing of tools that guide the organization toward sustainable practices and indicate how the same organization contributes to a global Sustainable Development (SD).
Anastasiia Moldavska, T. Welo
semanticscholar   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

EGRESS: A Methodology for Eliciting Goals for Requirements Engineering of Secure Systems

IEEE Open Journal of Systems Engineering
Currently, the systems engineering body of knowledge does not appropriately address secure system design considerations prior to a preliminary architecture being available for the system under design.
Martin Span, Gabe Salinger, Jeremy Daily
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source