Results 21 to 30 of about 73,201 (215)

Piecewise continuous approach to nonlinear differential equations approximation problem of computational structural mechanics

open access: yesMATEC Web of Conferences, 2018
This paper presents a nonlinear differential equations system piecewise continuous approximation. The piecewise continuous approximation improves piecewise linear approximation through reducing the errors at the boundaries of different linear ...
Leibov Roman
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Fuzzy Differential Equations for Nonlinear System Modeling With Bernstein Neural Networks

open access: yesIEEE Access, 2016
With the fuzzy set theory, the uncertainty of nonlinear systems can be modeled using fuzzy differential equations. The solutions of these equations are the model output, but they are very difficult to obtain.
Raheleh Jafari, Wen Yu, Xiaoou Li
doaj   +1 more source

Invariant subspaces, exact solutions and stability analysis of nonlinear water wave equations

open access: yesJournal of Ocean Engineering and Science, 2020
The key purpose of the present research is to derive the exact solutions of nonlinear water wave equations (NLWWEs) in oceans through the invariant subspace scheme (ISS).
K. Hosseini   +6 more
doaj   +1 more source

Impact Response Prediction Method of Packaging Systems with a Key Component considering Different Excitations and Cushioning Materials

open access: yesShock and Vibration, 2022
Nonlinear dynamic models of the packaging systems that consider different excitations and cushioning materials are proposed to analyze their impact responses in this paper.
Heye Xiao   +5 more
doaj   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

open access: yesFEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake   +4 more
wiley   +1 more source

Approximate Methods for Solving Problems of Mathematical Physics on Neural Hopfield Networks

open access: yesMathematics, 2022
A Hopfield neural network is described by a system of nonlinear ordinary differential equations. We develop a broad range of numerical schemes that are applicable for a wide range of computational problems.
Ilya Boykov   +2 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source

Digital Cognitive Phenotyping for Differential Diagnosis and Monitoring in Neurological Conditions

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the utility, accessibility, and equivalence to supervised scales of online cognitive assessment in older individuals with cognitive impairment. Methods Patients with Alzheimer's disease (AD, n = 31), idiopathic normal pressure hydrocephalus (iNPH, n = 26), and traumatic brain injury (TBI, n = 23) completed online cognitive ...
Martina Del Giovane   +10 more
wiley   +1 more source

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