Results 261 to 270 of about 2,984,717 (307)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis
Molecular Oncology, EarlyView.LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini +1 more
wiley +1 more source
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SCIENCE AND THE SYSTEMS PARADIGM†
International Journal of General Systems, 1976We live in a largely artificial world, one made by man as a result of the most powerful activity man has discovered: the activity of science. The intellectual and practical adventure which began in Western Europe in the 16th and 17th Centuries with Copernicus, Kepler, Galileo, Newton, has made our world.
exaly +2 more sources
Science, 2012
In his Essay “Systems science for policy evaluation” (15 June, p. [1398][1]), P. Kabat argued that we need to use systems science to inform better public policy. We agree completely. But why don't more sustainability scientists actively advocate and practice systems science?
Dargusch, Paul, Smith, Carl
openaire +4 more sources
In his Essay “Systems science for policy evaluation” (15 June, p. [1398][1]), P. Kabat argued that we need to use systems science to inform better public policy. We agree completely. But why don't more sustainability scientists actively advocate and practice systems science?
Dargusch, Paul, Smith, Carl
openaire +4 more sources
53rd IEEE Conference on Decision and Control, 2014
As the internet becomes the information-technology backbone for more and more operations, including critical infrastructures such as water and power systems, the security problems introduced by linking such operations to the internet become more of a concern.
Ann Cox, Sandip Roy 0002, Sean Warnick
openaire +1 more source
As the internet becomes the information-technology backbone for more and more operations, including critical infrastructures such as water and power systems, the security problems introduced by linking such operations to the internet become more of a concern.
Ann Cox, Sandip Roy 0002, Sean Warnick
openaire +1 more source
Science, 2001
O ne of the great scientific challenges of the 21st century is to forecast the future of planet Earth. As human activities push atmospheric carbon dioxide (CO2) and methane concentrations far beyond anything seen for nearly half a million years (prompting the strongest statement yet from the Intergovernmental Panel on Climate Change that human ...
openaire +2 more sources
O ne of the great scientific challenges of the 21st century is to forecast the future of planet Earth. As human activities push atmospheric carbon dioxide (CO2) and methane concentrations far beyond anything seen for nearly half a million years (prompting the strongest statement yet from the Intergovernmental Panel on Climate Change that human ...
openaire +2 more sources