Results 91 to 100 of about 5,861,762 (284)
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Nonlinear Min-Cost-Pursued Route-Swapping Dynamic System
Discrete Dynamics in Nature and Society, 2013 This study proposes a nonlinear min-cost-pursued swapping dynamic (NMSD) system to model the evolution of selfish routing games on traffic network where travelers only swap from previous costly routes to the least costly ones. NMSD is a rational behavior
Wenyi Zhang +3 more
doaj +1 more source
Forecasting Promotional Sales Within the Neighbourhood
IEEE Access, 2019 Promotions are a widely used strategy to engage consumers and as such, retailers dedicate immense effort and resources to their planning and forecasting.
Carlos Aguilar-Palacios +2 more
doaj +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Discrete Dynamics in Nature and Society, 2012 The operational efficiency and safety of pedestrian flows at intersections is an important aspect of urban traffic. Particularly, conflicts between pedestrians and vehicles in crosswalk are one of the most influential factors for intersection safety ...
Xiaomeng Li +3 more
doaj +1 more source
IEEE Access, 2018 Location selection for urban distribution centers (DCs) is vital in saving distribution cost and reducing the negative externalities arising from freight transportation.
Shilong Li, Zhenlin Wei, Ailing Huang
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
An Improved Deep Learning Model for Traffic Crash Prediction
Journal of Advanced Transportation, 2018 Machine-learning technology powers many aspects of modern society. Compared to the conventional machine learning techniques that were limited in processing natural data in the raw form, deep learning allows computational models to learn representations ...
Chunjiao Dong +3 more
doaj +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source