Results 81 to 90 of about 694,403 (269)
Forecasting Promotional Sales Within the Neighbourhood
IEEE Access, 2019 Promotions are a widely used strategy to engage consumers and as such, retailers dedicate immense effort and resources to their planning and forecasting.
Carlos Aguilar-Palacios +2 more
doaj +1 more source
The Systemic Theory of Living Systems and Relevance to CAM: The Theory (Part II) [PDF]
Evidence-Based Complementary and Alternative Medicine, 2005 This theory stems from observing the universe′s ‘omniscient’ nature, manifested in flows of energy and information of its life plethora. A notorious example is the living cell′s intelligent nature, which guides its basic goal: to maximize survival.
openaire +4 more sources
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Discrete Dynamics in Nature and Society, 2012 The operational efficiency and safety of pedestrian flows at intersections is an important aspect of urban traffic. Particularly, conflicts between pedestrians and vehicles in crosswalk are one of the most influential factors for intersection safety ...
Xiaomeng Li +3 more
doaj +1 more source
IEEE Access, 2018 Location selection for urban distribution centers (DCs) is vital in saving distribution cost and reducing the negative externalities arising from freight transportation.
Shilong Li, Zhenlin Wei, Ailing Huang
doaj +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
An Improved Deep Learning Model for Traffic Crash Prediction
Journal of Advanced Transportation, 2018 Machine-learning technology powers many aspects of modern society. Compared to the conventional machine learning techniques that were limited in processing natural data in the raw form, deep learning allows computational models to learn representations ...
Chunjiao Dong +3 more
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source