Results 91 to 100 of about 5,972,586 (343)
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Cold-Start Promotional Sales Forecasting Through Gradient Boosted-Based Contrastive Explanations
IEEE Access, 2020 Multiple Machine Learning solutions in Industry exist where interpretability is required. In retail, this is especially important when dealing with cold-start forecasting of promotional sales.
Carlos Aguilar-Palacios +2 more
doaj +1 more source
Rerepresenting and Restructuring Domain Theories: A Constructive Induction Approach
, 1995 Theory revision integrates inductive learning and background knowledge by combining training examples with a coarse domain theory to produce a more accurate theory. There are two challenges that theory revision and other theory-guided systems face. First,
Donoho, S. K., Rendell, L. A.
core +2 more sources
Self-Consistent Theory of Bose-Condensed Systems
, 2006 In the theory of Bose-condensed systems, there exists the well known problem, the Hohenberg-Martin dilemma of conserving versus gapless approximations. This dilemma is analysed and it is shown that it arises because of the internal inconsistency of the ...
Andersen +40 more
core +2 more sources
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Theory of reliable systems [PDF]
An attempt was made to refine the current notion of system reliability by identifying and investigating attributes of a system which are important to reliability considerations.
Meyer, J. F.
core +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Bloch Theory and Quantization of Magnetic Systems
, 2000 Quantizing the motion of particles on a Riemannian manifold in the presence of a magnetic field poses the problems of existence and uniqueness of quantizations.
Asch +9 more
core +3 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source