Results 61 to 70 of about 685,370 (269)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Complexity Theory for Splicing Systems
Theoretical Computer Science, 2007 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Remco Loos, Mitsunori Ogihara
openaire +2 more sources
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Sensors, 2014 Tactile sensors play an important role in robotics manipulation to perform dexterous and complex tasks. This paper presents a novel control framework to perform dexterous manipulation with multi-fingered robotic hands using feedback data from tactile and
Carlos A. Jara +3 more
doaj +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Dynamic Congested Traffic States of Density Difference Lattice Hydrodynamic Model with On-Ramp
Discrete Dynamics in Nature and Society, 2013 The density difference lattice hydrodynamic model with on-ramp is proposed. Stochastic and deterministic rules for the on-ramp flow entering into the main road are designed. Under the stochastic rule, various empirical spatiotemporal patterns can be well
Jun-fang Tian +3 more
doaj +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Timetable Design for Urban Rail Line with Capacity Constraints
Discrete Dynamics in Nature and Society, 2015 To design an efficient and economical timetable for a heavily congested urban rail corridor, a scheduling model is proposed in this paper. The objective of the proposed model is to find the departure time of trains at the start terminal to minimize the ...
Yu-Ting Zhu +3 more
doaj +1 more source
Toward an algebraic theory of systems
Theoretical Computer Science, 2018 We propose the concept of a system algebra with a parallel composition operation and an interface connection operation, and formalize composition-order invariance, which postulates that the order of composing and connecting systems is irrelevant, a generalized form of associativity.
Christian Matt 0002 +4 more
openaire +5 more sources