Results 71 to 80 of about 18,160 (234)

A Systems Thinking Approach to Understanding Public Trust in Healthcare Services and Doctor-patient Relationship in the Contexts of Medical Errors [PDF]

, 2020
Phanuwich Kaewkamjonchai, Peeraya Piancharoen, Kornkanok Saringkarisate, Sorrawit Rojcheewin, Pongpat Wananukul, Adithep Suttawas, Gunkawee Sriyudtha, Piyawan Limpanyalert, Borwornsom Leerapan   +8 more
openalex   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Ta-Da! You’re a Design Thinker! Validating the DesignShop as a Model for Teaching Design Thinking to Non-Designers and Achieving Systemic Re-Design in the Education System [PDF]

, 2015
Jessica A. Artiles, Katherine Gordy Levine   +1 more
openalex   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Inter-Work and Ethical Vigilance: Two Scenarios for the (Post-)Pandemic Future of Systems Thinking [PDF]

, 2020
José‐Rodrigo Córdoba‐Pachón
openalex   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Emergency Medical Services Clinicians and COVID-19 Booster Behavior—A Cross-Sectional National Evaluation

Vaccines
Background/Objectives: Emergency Medical Services (EMS) clinicians in the US have high COVID-19 vaccine hesitancy rates and often do not receive primary vaccinations or subsequent boosters.
Gregory Muller, Christopher B. Gage, Jonathan R. Powell, Sarah R. MacEwan, Laura J. Rush, Eben Kenah, Gennaro Di Tosto, Ann Scheck McAlearney, Ashish R. Panchal   +8 more
doaj   +1 more source

Patient portal messaging for care coordination: a qualitative study of perspectives of experienced users with chronic conditions

BMC Family Practice, 2019
Background Patient portal secure messaging (asynchronous electronic communication between physicians and their established patients) allows patients to manage their care through asynchronous, direct communication with their providers.
Jennifer L. Hefner, Sarah R. MacEwan, Alison Biltz, Cynthia J. Sieck   +3 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

3.3.2 Collaborative Systems Thinking: A response to the problems faced by Systems Engineering's “middle tier” [PDF]

, 2009
Barbara Pfarr, Caroline Twomey Lamb, Maria M. So, Donna H. Rhodes   +3 more
openalex   +1 more source