Results 91 to 100 of about 2,005,886 (312)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

COVID‐19 and coworker conflict among emergency medical service clinicians

Journal of the American College of Emergency Physicians Open
Objectives Safety policies enacted in response to the emergence of coronavirus disease 2019 (COVID‐19) have greatly affected the working environments of emergency medical service (EMS) clinicians.
Gennaro Di Tosto, Halia Melnyk, Jonathan R. Powell, Eben Kenah, Christopher B. Gage, Ashish R. Panchal, Ann Scheck McAlearney   +6 more
doaj   +1 more source

Community coalitions’ navigation of policies to address the opioid epidemic: insights from qualitative interviews in four states

BMJ Public Health
Introduction The opioid epidemic in the USA presents a multifaceted challenge regulated by a patchwork of federal, state and local policies. In some communities, cross-sector coalitions navigate this complex policy environment to address the epidemic ...
Elizabeth N Kinnard, Ann Scheck McAlearney, Timothy Hunt, Ramona G Olvera, Allyson G Cogan, Mary Bartkus, Shoshana N Benjamin, Jill Davis, Lisa A Frazier, Brandy F Henry, Hallie Mattingly, Dean Rivera, Mari-Lynn Drainoni, Daniel M Walker   +13 more
doaj   +1 more source

Systems practice in engineering: reflections on doctoral level systems supervision [PDF]

, 2011
The Industrial Doctorate Centre (IDC) in Systems, a collaboration between the University of Bristol and the University of Bath, offers an Engineering Doctorate (EngD) in Systems Programme which is aimed at high-calibre engineers from graduate level to ...
Yearworth, M
core  

Collaborative Systems Thinking Research: Exploring Systems Thinking within Teams [PDF]

, 2008
This paper describes ongoing research that seeks to develop an empirical basis for collaborative systems thinking, defined as “an emergent behavior of teams resulting from the interactions of team members and utilizing a variety of thinking styles ...
Beder, Bernold, Checkland, Clup, Cooke, Davidz, Davidz, Dong, Dorner, Dym, Entin, Frank, Gharajedaghi, Gigerense, Glaser, Hackman, Jansma, Lamb, Lamb, Lerch, Lynn, Mohammed, Pajerek, Richmond, Saunders, Schein, Senge, Stephens, Sterman, Strauss, Sweeney, Thompson, Utter, Volger, Waszakm, Wesenberg, Yin   +36 more
core   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Social and Ecological Responsibility: A Critical Systemic Perspective [PDF]

, 2003
The notion of systemic thinking for social and ecological responsibility is deconstructed and its holistic potential examined from a critical systemic perspective informed by the ideas of the systems philosopher, C. West-Churchman.
Reynolds, Martin
core  

Collaborative Systems Thinking: Towards an Understanding of Team-level Systems Thinking [PDF]

, 2008
As the engineering workforce ages, skills with long development periods are lost with retiring individuals faster than are younger engineers developing the skills. Systems thinking is one such skill.
Kissane, M.P., Perkins, Richard J., Reeks, M.W., Zhang, F.   +3 more
core   +4 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source