Results 91 to 100 of about 25,959,890 (353)
Thinking in risky places as systems
The chapter introduces the fundamental concepts of systems thinking used in this book. We advocate for systems thinking as a framework for developing sustainable crime prevention for risky places.
Newton, Andy, Ceccato, Vania
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
BMC Health Services ResearchBackground Despite calls for regionalizing pancreatic cancer (PC) care to high-volume centers (HVCs), many patients with PC elect to receive therapy closer to their home or at multiple institutions.
Matthew J. DePuccio +7 more
doaj +1 more source
Incubating service systems thinking: New frames for collaborating on a pattern language for service systems [PDF]
, 2014 “Service systems thinking” is proffered as a label for an emerging body of work that: (i) builds on social systems thinking (i.e. socio-psychological, socio-technical and socio-ecological systems perspectives) to advance a transdisciplinary appreciation ...
Ing, David
core
Collaborative Systems Thinking: Uncovering the rules of team-level systems thinking [PDF]
, 2009 As the aerospace workforce braces itself for the 'silver tsunami,' more emphasis is needed on how to develop systems skills in engineering workforce research has shown this knowledge is tacit and based in experience. However, with nearly one-third of the
Caroline Twomey Lamb +4 more
core +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Information systems, software engineering, and systems thinking: challenges and opportunities [PDF]
, 2008 This article traces past research on the application of the systems approach to information systems development within the disciplines of information systems and software engineering. Their origins historically are related to a number of areas, including
O'Connor, Rory +11 more
core +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Using systems thinking to create more impactful social policy [PDF]
, 2015 This article proposes that “systems thinking” offers a way of (a) diagnosing the potential effectiveness of social policy and (b) of creating more impactful social policy.
Julia Canty-Waldron
core