Results 91 to 100 of about 10,335,785 (256)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Information systems, software engineering, and systems thinking: challenges and opportunities [PDF]

, 2008
This article traces past research on the application of the systems approach to information systems development within the disciplines of information systems and software engineering. Their origins historically are related to a number of areas, including
O'Connor, Rory, Petkov, D., Petkov, Doncho, Denis Edgar-Nevill, Raymond Madachy, Rory O’Connor, O'Connor, R., Edgar-Nevill, Denis, Madachy, R., Madachy, Raymond, Doncho Petkov, Edgar-Nevill, D.   +11 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Systems Thinking: An introduction for Oxfam programme staff

, 2015
Development organizations frequently face and overcome challenges in programme delivery. But what happens when the proposed solutions fail? How can organizations adapt to changing conditions and ensure the benefits of programmes are shared as widely as ...
Whitehead, James, Jeans, Helen, Chettleborough, John, Rowlands, Jo, Bowman, Kimberly   +4 more
core  

Age, comorbidity, race and gender differences in referral to a pulmonologist among patients with sarcoidosis at a large academic medical center

BMC Pulmonary Medicine
Background Prior work has reported differences in the prevalence of sarcoidosis as well as patient outcomes based on race, gender, and socioeconomic status.
John Odackal, Gennaro Di Tosto, Ann Scheck McAlearney, Laura J. Rush, Elliott Crouser, Michelle Sharp   +5 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Activating systems thinking for sustainable crime prevention

This chapter reflects on the two main purposes of this book. The first was to better understand the intricacies and nuances of risky places for crime.
Newton, Andy, Ceccato, Vania, Ceccato, Vania,, Newton, Andy,   +3 more
core   +1 more source

An Identification of Normative Sources for Systems Thinking : an Inquiry into Religious Ground-Motives for Systems Thinking Paradigms

, 2003
In celebration of C. West Churchman's work, this article investigates one of the most cherished endeavours of his thinking: to provide a normative meaning for the conduct of human affiars.
Haftor, Darek,
core   +1 more source