Results 111 to 120 of about 2,005,886 (312)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Emergency Medical Services Clinicians and COVID-19 Booster Behavior—A Cross-Sectional National Evaluation

Vaccines
Background/Objectives: Emergency Medical Services (EMS) clinicians in the US have high COVID-19 vaccine hesitancy rates and often do not receive primary vaccinations or subsequent boosters.
Gregory Muller, Christopher B. Gage, Jonathan R. Powell, Sarah R. MacEwan, Laura J. Rush, Eben Kenah, Gennaro Di Tosto, Ann Scheck McAlearney, Ashish R. Panchal   +8 more
doaj   +1 more source

Bells that still can ring: systems thinking in practice [PDF]

, 2011
Complexity science has generated significant insight regarding the interrelatedness of factors and actors constituting our real world and emergent effects from such interrelationships.
Reynolds, Martin
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Predicting Individual Systems Thinking Skills Using Bayesian Network Approach

IEEE Access
Emergence in complex systems is often compounded by diverse information and rapid technological acceleration. The problems and behaviors of increasingly complex systems continue confining practitioners’ systems engineering capabilities to maintain
Niamat Ullah Ibne Hossain, Raed Jaradat, Morteza Nagahi, Alex Gorod   +3 more
doaj   +1 more source

Systems Thinking is Inclusive Thinking

Library Leadership & Management
Today’s organizations are making a concerted effort to demonstrate greater inclusivity in their workplace practices, their processes, and their larger cultures. Research has shown diverse organizations are more innovative, adaptable, and regarded as better places to work by current and potential employees.
openaire   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Ritual and Systems Thinking

Journal of Awareness-Based Systems Change
This book review offers Norma Romm’s detailed reading of José-Rodrigo Córdoba-Pachón’s new book Ritual and Systems Thinking: Managing an Initial Encounter (Routledge 2024).
Norma Romm
doaj   +1 more source