Results 121 to 130 of about 10,335,785 (256)

Emergency Medical Services Clinicians and COVID-19 Booster Behavior—A Cross-Sectional National Evaluation

Vaccines
Background/Objectives: Emergency Medical Services (EMS) clinicians in the US have high COVID-19 vaccine hesitancy rates and often do not receive primary vaccinations or subsequent boosters.
Gregory Muller, Christopher B. Gage, Jonathan R. Powell, Sarah R. MacEwan, Laura J. Rush, Eben Kenah, Gennaro Di Tosto, Ann Scheck McAlearney, Ashish R. Panchal   +8 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

The systems thinking approach to strategic management

This paper presents a review of the field of systems thinking and strategic management The evolution of the areas of interest between systems thinking and strategic management follows similar patterns with more prescriptive developments occurring within ...
Kunc, Martin, Martin Kunc
core   +1 more source

Predicting Individual Systems Thinking Skills Using Bayesian Network Approach

IEEE Access
Emergence in complex systems is often compounded by diverse information and rapid technological acceleration. The problems and behaviors of increasingly complex systems continue confining practitioners’ systems engineering capabilities to maintain
Niamat Ullah Ibne Hossain, Raed Jaradat, Morteza Nagahi, Alex Gorod   +3 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Ritual and Systems Thinking

Journal of Awareness-Based Systems Change
This book review offers Norma Romm’s detailed reading of José-Rodrigo Córdoba-Pachón’s new book Ritual and Systems Thinking: Managing an Initial Encounter (Routledge 2024).
Norma Romm
doaj   +1 more source

Systems thinking, systems doing [PDF]

Nature Food, 2020
openaire   +2 more sources

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Systems Thinking: Common Ground or Untapped Territory? [PDF]

, 2011
At gatherings of the International Society for the Systems Sciences, the term “systems thinking” elicits understanding nods and smiles. Such thinking, it would appear, is a way this largely academic community works “all together now,” thinking in a ...
Chen, Wan-Ching, Buckle Henning, Pamela
core