Results 121 to 130 of about 249,834 (309)
SystemsCyberattacks increasingly generate systemic economic and geopolitical effects in an era of dense global interdependence. While prior research emphasises geopolitical rivalry, institutional capacity, and technological sophistication as determinants of ...
Zlatan Morić +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Economic Growth and Sustainability Systems Thinking for a Complex World
, 2015 How to sustain our world for future generations has perplexed us for centuries. We have reached a crossroads: we may choose the rocky path of responsibility or continue on the paved road of excess that promises hardship for our progeny.
Higgins, Karen L.
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VaccinesBackground/Objectives: Emergency Medical Services (EMS) clinicians in the US have high COVID-19 vaccine hesitancy rates and often do not receive primary vaccinations or subsequent boosters.
Gregory Muller +8 more
doaj +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Teaching Holistic Systems Thinking
, 2022 My wife and I got into systems theory by teaching parenting classes in the Inner-City of Winnipeg.
Johannson, Robert
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Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Systems Thinking: An introduction for Oxfam programme staff
, 2015 Development organizations frequently face and overcome challenges in programme delivery. But what happens when the proposed solutions fail? How can organizations adapt to changing conditions and ensure the benefits of programmes are shared as widely as ...
Whitehead, James +4 more
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Systems Thinking in an Age of Complexity
, 2020 The world has become increasingly networked and unpredictable. Decision-makers at all levels are required to manage the consequences of complexity every day.
Jackson, Michael
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Predicting Individual Systems Thinking Skills Using Bayesian Network Approach
IEEE AccessEmergence in complex systems is often compounded by diverse information and rapid technological acceleration. The problems and behaviors of increasingly complex systems continue confining practitioners’ systems engineering capabilities to maintain
Niamat Ullah Ibne Hossain +3 more
doaj +1 more source