Results 121 to 130 of about 2,005,886 (312)
Towards a million change agents. A review of the social movements literature: implications for large scale change in the NHS. [PDF]
, 2004 This review explores 'social movements' as a new way of thinking about large-scale systems change and assesses the potential contribution of applying this new perspective to NHS ...
Bate, SP, Bevan, H, Robert, G
core
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
eCustoms Case Study: Mechanisms behind Co-operation Planning [PDF]
, 2009 Members of existing e-commerce trading networks constantly assess their network to identify opportunities for increased co-operation and integration of e-commerce IT systems. Failing to identify the mechanisms involved in co-operation compromises correct
Eck, P.A.T., Ponisio, M.L., Riemens, L.
core +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Systems Thinking and Entrepreneurial Persistence Among Technology Entrepreneurs in China
SystemsBased on the theoretical framework of systems thinking, this study investigates the mechanism of systems thinking in promoting entrepreneurial persistence among technology entrepreneurs in China’s digital economy development.
Zhuo Tao, Jianmin Sun
doaj +1 more source
Moving on - beyond lean thinking [PDF]
, 2004 Lean Thinking is currently often positioned as the underlying theory of lean production among practitioners and academics, although its originators, Womack and Jones, seem not to have presented it as a theory.
Koskela, LJ
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Key competency development and students use of digital learning objects [PDF]
, 2012 The inclusion of key competencies in the New Zealand Curriculum (2007) has presented challenges for teachers in their efforts to gather evidence and detail student progress for reporting purposes.
Falloon, Garry
core +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source