Results 101 to 110 of about 10,335,785 (256)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Leveraging real-world data for population health outcomes research: evaluating all-cause mortality in stroke hospitalization using a statewide health information exchange

Critical Public Health
Inpatient stroke mortality remains high at 2–5% in the U.S. This retrospective cohort study evaluated all-cause mortality in ischemic stroke hospitalizations using real-world data from a mature health information exchange (HIE) over a 17-year period ...
Pallavi Jonnalagadda, Brian E. Dixon, Linda S. Williams, Saurabh Rahurkar   +3 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Service Systems Innovation for Treatment of Post-Traumatic Stress in the U.S. Military: An Enterprise Systems Approach [PDF]

, 2010
This presentation discusses the concept of enterprise systems thinking and its application to providing effective healthcare services.
Nightingale, Deborah J.
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Undergraduates’ Conceptualization of Systems Thinking

Systems
This study investigated undergraduates’ conceptualization of systems thinking (ST). An open-ended question was administered pre- and post-course. Pre-test findings revealed limited conceptualization, with most students unable to articulate core ST ...
Bellam Sreenivasulu, R. Subramaniam
doaj   +1 more source

Systems Thinking is Inclusive Thinking

Library Leadership & Management
Today’s organizations are making a concerted effort to demonstrate greater inclusivity in their workplace practices, their processes, and their larger cultures. Research has shown diverse organizations are more innovative, adaptable, and regarded as better places to work by current and potential employees.
openaire   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

COVID‐19 and coworker conflict among emergency medical service clinicians

Journal of the American College of Emergency Physicians Open
Objectives Safety policies enacted in response to the emergence of coronavirus disease 2019 (COVID‐19) have greatly affected the working environments of emergency medical service (EMS) clinicians.
Gennaro Di Tosto, Halia Melnyk, Jonathan R. Powell, Eben Kenah, Christopher B. Gage, Ashish R. Panchal, Ann Scheck McAlearney   +6 more
doaj   +1 more source

Community coalitions’ navigation of policies to address the opioid epidemic: insights from qualitative interviews in four states

BMJ Public Health
Introduction The opioid epidemic in the USA presents a multifaceted challenge regulated by a patchwork of federal, state and local policies. In some communities, cross-sector coalitions navigate this complex policy environment to address the epidemic ...
Elizabeth N Kinnard, Ann Scheck McAlearney, Timothy Hunt, Ramona G Olvera, Allyson G Cogan, Mary Bartkus, Shoshana N Benjamin, Jill Davis, Lisa A Frazier, Brandy F Henry, Hallie Mattingly, Dean Rivera, Mari-Lynn Drainoni, Daniel M Walker   +13 more
doaj   +1 more source