Results 81 to 90 of about 4,691,153 (264)

Polymorphisms in the WNK1 gene are asociated with blood pressure variation and urinary potassium excretion [PDF]

, 2009
WNK1 - a serine/threonine kinase involved in electrolyte homeostasis and blood pressure (BP) control - is an excellent candidate gene for essential hypertension (EH). We and others have previously reported association between WNK1 and BP variation. Using
Hoti, M, Caulfield, M, Lee, K, Samani, NJ, Elliott, P, Collins, R, Org, E, Farrall, M, Newhouse, S, Juhanson, P, Connell, JM, Ji, C, Burke, B, Viigimaa, M, Shaw-Hawkins, S, Veldre, G, Dobson, R, Kumari, M, Lathrop, GM, Iacone, R, Brunner, E, Dominiczak, AF, Strazzullo, P, Eyheramendy, S, Onipinla, A, Clarke, R, Chambers, J, Howard, P, Cappucio, FP, Marmot, M, Munroe, PB, Wallace, C, Kooner, J, Brown, M, Laan, M   +34 more
core  

Long‐Term Exposure to Elevated Systolic Blood Pressure in Predicting Incident Cardiovascular Disease: Evidence From Large‐Scale Routine Electronic Health Records

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background How measures of long‐term exposure to elevated blood pressure might add to the performance of “current” blood pressure in predicting future cardiovascular disease is unclear.
Jose Roberto Ayala Solares, Dexter Canoy, Francesca Elisa Diletta Raimondi, Yajie Zhu, Abdelaali Hassaine, Gholamreza Salimi‐Khorshidi, Jenny Tran, Emma Copland, Mariagrazia Zottoli, Ana‐Catarina Pinho‐Gomes, Milad Nazarzadeh, Kazem Rahimi   +11 more
doaj   +1 more source

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

Printable Piezoresistive Hybrid Hydrogels Based on 2D MoS2 for Flexible Pulse Sensing

Advanced Science, EarlyView.
Hybrid 1T‐MoS2‐based hydrogels are engineered through UV curing and 3D printing to achieve tunable electromechanical properties for wearable sensing. These soft architectures enhance mechanical stability and reproducible piezoresistive responses within the physiological pressure range.
Jenny Flores, Arianna Bertero, Luca Ceseracciu, Daniel Jiménez‐Boland, Sara Domenici, Mattia Bramini, Paola Sánchez‐Moreno, Erica Scarcelli, Domenico Galdiero, Pavel Fedorov, Daniil Karnaushenko, Rossella Sesia, Ignazio Roppolo, Micaela Pozzati, Mattia Spedicati, Nicolò Petrini, Marco Sangermano, Bartolomeo Coppola, Teresa Gatti   +18 more
wiley   +1 more source

BRACHIAL-TO-RADIAL-SYSTOLIC-BLOOD-PRESSURE-AMPLIFICATION AND THE IMPACT ON NON-INVASIVELY DERIVED CENTRAL SYSTOLIC BLOOD PRESSURE

, 2014
BRACHIAL-TO-RADIAL-SYSTOLIC-BLOOD-PRESSURE-AMPLIFICATION AND THE IMPACT ON NON-INVASIVELY DERIVED CENTRAL SYSTOLIC BLOOD ...
DS Picone (15795698), RED Climie (14535080), KDK Ahuja (15795704), Michelle Keske (13078767), JE Sharman (14474352)   +4 more
core  

Invasive Aortic, Brachial, and Cuff-based Blood Pressures: Their Impact on Hypertension Risk Assessment and Management

Indian Journal of Clinical Cardiology
Hypertension, the most common modifiable risk factor for “cardiovascular disease” burden, with mortality risk doubling for each 20/10 mmHg blood pressure increase above 115/75 mmHg.
N. Balamurugan, T. M. Ibrahim Thaha, Aravind A., Arumugam M. A., Elamaran C.   +4 more
doaj   +1 more source

VARIABILITAS TEKANAN DARAH INTRADIALISIS PASIEN PENYAKIT GINJAL KRONIS DENGAN HEMODIALISIS BERKELANJUTAN

Majalah Biomorfologi, 2019
Background: Various of studies report there was a link between changes in blood pressure during hemodialysis and the level of patient’s morbidity and mortality.
Maulana Muhtadin Suryansyah, Mochammad Thaha, Budiono Budiono   +2 more
doaj   +1 more source

Increased Disarray of Extracellular Matrix Collagen‐I Fiber Network and Compromised Biomechanics in Aortae From Marfan‐Syndrome Mice Assessed Through Combined Opto‐Biomechatronics

Advanced Science, EarlyView.
Combined structure‐function assessment in aortic rings from Marfan mice using MechaMorph Opto‐Biomechatronics technology relates increased elasticity (stiffness) and dynamic viscosity and less ordered extracellular matrix 3D‐structure (collagen) as potential causes for impaired Windkessel function and compromised haemodynamics in Marfan's syndrome ...
Dominik Schneidereit, Anika Nagel, Vanessa I. T. Zwaans, Laureen Schurr, Jonas Ahr, Michael Haug, Anna Piluso, Alexandra Sporkova, Matthias Karck, Andreas H. Wagner, Oliver Friedrich   +10 more
wiley   +1 more source

Conference on "Multidisciplinary approaches to nutritional problems". Postgraduate Symposium. Exploiting dietary supplementation trials to assess the impact of the prenatal environment on CVD risk. [PDF]

, 2008
Animal studies have demonstrated that altering the maternal diet during pregnancy affects offspring disease risk. Data from human subjects on the early-life determinants of disease have been derived primarily from birth-weight associations; studies of ...
Hawkesworth, Sophie, Sophie Hawkesworth
core   +1 more source

Gut Microbiota‐Derived Indole‐3‐Propionic Acid Alleviates Diabetic Osteoporosis Through Nrf2‐Mediated Ferroptosis Suppression

Advanced Science, EarlyView.
Diabetes‐associated dysbiosis is accompanied by reduced Clostridium abundance, impaired microbial tryptophan metabolism, and lower circulating indole‐3‐propionic acid (IPA). Exogenous IPA improves trabecular microarchitecture and bone formation and restores Nrf2‐associated antioxidant signaling in bone marrow mesenchymal stem cells, limiting iron ...
Jinwu Bai, Qinyong You, Gao Si, Daole Hu, Ao Sun, Shilong Su, Ruideng Wang, Jixing Fan, Shan Gao, Tengjiao Zhu, Chun‐Li Song, Fang Zhou, Yang Lv   +12 more
wiley   +1 more source