Results 121 to 130 of about 5,393,834 (251)

Safety and pharmacokinetics of mosliciguat, a new, inhaled soluble guanylate cyclase activator, in healthy adult subjects

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mosliciguat (BAY 1237592), the first soluble guanylate cyclase (sGC) activator in a dry powder inhaler (DPI), could potentially treat pulmonary hypertension with a more targeted delivery than systemic sGC stimulators. We report safety and tolerability of mosliciguat in healthy men.
Johannes Nagelschmitz, Soundos Saleh, Sandra Ligges, Melanie Seidel‐Greven, Eva Becker‐Pelster, Sylvia M. Nikkho, Stefanie Boxnick, Wolfgang Timmer   +7 more
wiley   +1 more source

PROGNOSTIC VALUE OF AMBULATORY BLOOD PRESSURE MONITORING IN PATIENTS WITH EARLY-STAGE CEREBROVASCULAR DISEASE

Ukrainian Scientific Medical Youth Journal, 2016
Introduction. Hypertension is one of the major risk factors for cerebrovascular disease (CVD). The defeat of the cerebral vessels occurs within a certain time. The duration of this process depends on a number of blood pressure (BP) characteristics, which
M. Treschinskaya, I. Bel’skaya, I. Cimbalyuk   +2 more
doaj  

Influence of the Catecholamine Syringe Changeover Method on Patients’ Blood Pressure Variability: A Single-Center Retrospective Study

Nursing Reports
Background/Objectives: In Japan, evidence on catecholamine syringe exchange methods is limited, with practices varying across facilities and individuals.
Yuta Niitsu, Takumi Tsuchida, Ryuta Sato, Juna Shintaku, Koichi Iwasa   +4 more
doaj   +1 more source

Development of a nalmefene formulation suitable for a community‐use auto‐injector

British Journal of Clinical Pharmacology, EarlyView.
Aim Time to onset of reversal is critical when treating opioid‐induced respiratory depression and hypoxia. This study aimed to develop a formulation of the opioid antagonist nalmefene with an increased absorption rate and reduced time to onset of reversal following intramuscular administration. Methods Several absorption enhancers were screened in rats,
Alessandra Cipriano, Manjunath S. Shet, Hugh Huang, Ronnie Ortiz, Garth T. Whiteside, Glen Apseloff, Stephen C. Harris   +6 more
wiley   +1 more source

The impact of vascular calcification on ambulatory and central aortic blood pressure in a South African dwelling dialysis population : a clinical, radiological and pathophysiological study of vascular health in a young prevalent dialysis population in a developing country [PDF]

, 2011
Includes abstract.Includes bibliographical references.In Sub-Saharan Africa, the prevalence of vascular calcification (VC) in CKD-5D is unknown. We undertook to determine the effect of ethnicity on VC, the risk factors for VC, the utility of abdominal X ...
Freercks, Robert Jeremy
core   +1 more source

Acute effects of THC and a CBD+THC combination on cardiovascular haemodynamics and respiratory muscle activity during loaded breathing in healthy adults: A randomized placebo‐controlled crossover study

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to evaluate the acute effects of cannabidiol plus tetrahydrocannabinol (CBD+THC) and tetrahydrocannabinol (THC) oils on cardiovascular haemodynamics, respiratory muscle activity and peripheral tissue perfusion in healthy adults. Methods In this randomized, double‐blind, crossover trial, participants received orally administered ...
Edna Karla Ferreira Laurentino, Marina Lyra L. C. Fagundes, Bruno Lobão Soares, Rodrigo Torres‐Castro, Matias Otto‐Yañez, Emerson Arcoverde Nunes, Matheus Freitas Fernandes Pedrosa, Jéssica Danielle Medeiros da Fonsêca, Vanessa R. Resqueti, Guilherme Augusto de Freitas Fregonezi   +9 more
wiley   +1 more source

Economic evaluations of antiobesity medications: A systematic literature review

British Journal of Clinical Pharmacology, EarlyView.
The global prevalence of obesity is rising rapidly. With several antiobesity medications approved and many more in development, understanding their economic value is increasingly important. This study reviews full economic evaluations of approved antiobesity medications to assess cost‐effectiveness and inform reimbursement and access decisions.
Martina Jurković, Almir Fajkić, Andrea Katrin Faour, Mirna Momčilović, Petra Turčić, Andrej Belančić   +5 more
wiley   +1 more source

Association between systolic blood pressure variability and severity of cerebral amyloid angiopathy in incident intracerebral hemorrhage. [PDF]

Front Stroke, 2023
Moullaali TJ, Walters R, Rodrigues M, Samarasekera N, Bernal J, Wang X, Humphreys C, Wardlaw JM, Farrall A, Smith C, Anderson CS, Al-Shahi Salman R, McKinstry B.   +12 more
europepmc   +1 more source

Intraoperative Systolic Blood Pressure Variability Predicts 30-day Mortality in Aortocoronary Bypass Surgery Patients

, 2010
Background Few data support an association between blood pressure variability and clinical outcomes during cardiac surgery.
Mark Newman, Solomon Aronson, Mark Stafford-Smith, null null, Jeffrey Gaca, Barbara Phillips-Bute, Andrew Shaw   +6 more
core   +1 more source

Organizational Citizenship Behavior and Gray Matter Volume Among Japanese Workers: An Exploratory Cross‐Sectional Study

Brain Health, EarlyView.
ABSTRACT Introduction Organizational citizenship behavior (OCB) is generally considered beneficial to organizations, but extra‐role behavior may also impose costs on employees under some circumstances. Whether the workplace, personality, and neuroanatomical correlates of OCB differ between men and women remains unclear.
Keisuke Kokubun, Kiyotaka Nemoto, Yoshinori Yamakawa   +2 more
wiley   +1 more source