Results 101 to 110 of about 5,906,243 (300)

Wave reflection does not differ between patients with normal and with severely impaired systolic function

, 2014
Non-invasive estimates of wave reflection are independent prognostic markers in patients with normal systolic funciton, showing a direct relationship between the extent of ware reflection and cardiovascular risk.
Eber, Bernd, Hametner, Bernhard, Weber, Thomas, Wassertheurer, Siegfried, Bachler, Martin, Parragh, Stephanie   +5 more
core   +3 more sources

Echocardiographic left ventricular volumes, systolic function, strain and diastolic function.

, 2015
Data is presented as mean±SD. P-values refers to 2-way repeated measures ANOVA between the 2 training groups.# For statistical reasons, data was analyzed with three separate tests were performed to determine time, group and time*group P-values.
Arie P. J. van Dijk (820424), Maria T. E. Hopman (630881), Guus G. C. F. Stevens (820422), Bregina T. P. Hijmans-Kersten (820423), Evert J. P. Lamfers (820426), Louise Bellersen (820425), Nathalie M. M. Benda (820420), Dick H. J. Thijssen (587367), Joost P. H. Seeger (820421)   +8 more
core   +1 more source

Drug Repurposing for Treating NCOR‐Related Intellectual Disability

Advanced Science, EarlyView.
An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong, Wenjun Zhou, Yuxiang Sun, Zihan Huang, Zhiyue Liu, Udhaya Kumar. S, Chenyan Li, Yi Lu, Chengchuang Song, Veronica C. Ciliberto, Makenna Mack, Lana E. Kim, Zhaoyong Hu, Fang Luo, Aihua Cao, Zheng Sun   +15 more
wiley   +1 more source

Strain and strain rate by two-dimensional speckle tracking echocardiography in a maned wolf Strain e strain rate por meio de ecocardiogratia speckle traking bidimensional em um lobo-guará

Pesquisa Veterinária Brasileira, 2012
The measurement of cardiovascular features of wild animals is important, as is the measurement in pets, for the assessment of myocardial function and the early detection of cardiac abnormalities, which could progress to heart failure.
Matheus M. Mantovani, Adriana C. Silva, Ruthnéa A.L. Muzzi, Guilherme Oberlender, Rosane M. Resende, Leonardo A.L. Muzzi, Antonio C.C. Lacreta Junior, Rodrigo B. Nogueira   +7 more
doaj  

NCOA4 Accelerates Abdominal Aortic Aneurysm Formation by Regulating Macrophage Activation and Ferroptosis via STAT1–CH25H Axis

Advanced Science, EarlyView.
Under pathological stimulation, NCOA4 in macrophages interacts with STAT1 to promote CH25H transcription. The subsequent increase in 25‐HC production activates macrophages, triggers inflammatory responses and ferroptosis, and accelerates the progression of AAA.
Zhinan Wu, Yuxuan Qian, Wenyi Xu, Fei Liao, Xueliang Liu, Xiao Kuang, Guqing Luo, Xinjie He, Lixian Jiang, Song Ding   +9 more
wiley   +1 more source

Alkylating Agent–Induced FANCL Impairment Damages Pulmonary Arterial, Venous, and Microvascular Endothelial Cells and Predisposes to PAH/PVOD

Advanced Science, EarlyView.
This study establishes a novel cisplatin‐induced rat model of PAH/PVOD and identifies a conserved mechanistic axis—FANCL impairment, DNA damage accumulation, and endothelial dysfunction—triggered by cisplatin or mitomycin C across pulmonary arteries, veins, and microvessels.
Shiyun Liu, Yufei Sun, Xinlei Wu, Haixia Chen, Shaocong Mo, Zichong Li, Yiwei Gong, Xiaoqian Shan, Yuanqi Li, Yaru Guan, Junqi Zhu, Han Yan, Min Du, Feng Wei, Peixin Ou, Ziyi Wang, Chenting Zhang, Lei Xu, Wenju Lu, Jian Wang, Kai Yang   +20 more
wiley   +1 more source

Equivalent transformation on systolic design represented by generating function

, 2011
In this paper, we propose a method for representing and transforming a systolic design. For representing a systolic design, the generating function [3, 11, 13] is used.
Hou, Young-chang; Tsay, J. C.
core   +1 more source

Targeting Nupr1‐Mediated p53 Mitochondrial Sequestration Alleviates Aortic Dissection by Restoring the Gadd45b‐Dependent Survival Program

Advanced Science, EarlyView.
This study identifies Nupr1 as a crucial stress‐responsive orchestrator driving AD. Under severe stress, Nupr1 massively accumulates within mitochondria to sequester p53, triggering apoptosis and concurrently repressing the Gadd45b‐mediated survival program.
Xi Yang, Ke‐Yuan Chen, Yue Tian, Zong‐Sheng Jiang, Jian Lei, Xing‐Hui Zhuang, Jiang‐Bin Wu, Le‐Le Tang, Hao‐Yu Li, Xiao‐Hui Chen, Yue Wang, Yu‐Mei Li, Zhi‐Huang Qiu, Zi‐Wen Cai, Liang‐Wan Chen   +14 more
wiley   +1 more source

Assessment of right ventricular systolic function: Comparison between cardiac magnetic resonance derived ejection fraction and pulsed-wave tissue Doppler imaging of the tricuspid annulus

, 2011
Systolic right ventricular (RV) function is an important predictor in the course of various congenital and acquired heart diseases. Its practical determination by echocardiography remains challenging.
Stuber, Thomas, Praz, Fabien, Thomas Stuber, Hullin, Roger, Harald Bonel, Bernhard Meier, Jean-Paul Schmid, Koestner, Simon C, Schwerzmann, Markus, Fabien Praz, Markus Schwerzmann, Simon C. Koestner, Hess, Otto M, Roger Hullin, Christian Seiler, Bonel, Harald, Otto M. Hess, Schmid, Jean-Paul, Andreas Wahl, Delacrétaz, Etienne, Seiler, Christian, Etienne Delacrétaz, Wahl, Andreas, Meier, Bernhard, Seiler C, Hess OM, Hess, Otto, Schwerzmann M, Meier B, Schmid JP, Delacrétaz E, Bonel, Harald Marcel, Köstner, Simon Charles, Stuber T, Wahl A, Bonel H, Schmid-Walker, Jean-Paul, Hullin R, Praz F, Koestner SC   +39 more
core   +1 more source

Ultrasound‐Triggered piRNA Delivery Using Biomimetic Phase‐Changeable Nanoparticles for Theranostics of Myocardial Infarction

Advanced Science, EarlyView.
A biomimetic ultrasound‐responsive piRNA delivery nanoparticle platform (piR‐NPs) enables targeted delivery and ultrasound (US)‐triggered release of piR‐1873 in infarcted myocardium. The released piR‐1873 suppresses Usp2‐mediated RIP1/RIP3/MLKL necroptosis, reduces myocardial injury and fibrosis, and promotes cardiac functional recovery, providing a ...
Yajun Zhang, Hongzhao Qi, Yanyan Yang, Feng Wang, Tiantian Han, Yanbei Lei, Xiaolu Li, Zhibin Wang, Hua Qu, Tao Yu, Pin Sun   +10 more
wiley   +1 more source