Results 81 to 90 of about 5,906,243 (300)

SerpinA3 is an Endogenous TGF‐β Receptor Antagonist that Attenuates Cardiac Fibroblast Activation and Fibrotic Remodeling

open access: yesAdvanced Science, EarlyView.
SerpinA3 acts as an endogenous TGF‐β receptor antagonist that binds to the extracellular domain of TGFR‐1, thereby preventing TGFR‐1–TGFR‐2 complex formation. This receptor‐level blockade suppresses TGF‐β/Smad2/3 signaling, attenuates cardiac fibroblast activation, and extracellular matrix deposition, and ultimately alleviates pressure overload–induced
Hui Wang   +9 more
wiley   +1 more source

INFLUENCE OF C-TERMINAL TELOPEPTIDE OF TYPE I COLLAGEN AT LINEAR AND VOLUMETRIC CHARACTERISTICS OF LEFT VENTRICLE IN PATIENTS WITH CHRONIC HEART FAILURE

open access: yesКубанский научный медицинский вестник, 2016
In this study linear and three-dimensional left ventricle characteristic de-pending on the level of C-terminal telopeptide of type I collagen of 112 ischemic chronic heart failure patients with preserved and reduced systolic function have been studied ...
L. P. Voronina   +5 more
doaj  

Increased Disarray of Extracellular Matrix Collagen‐I Fiber Network and Compromised Biomechanics in Aortae From Marfan‐Syndrome Mice Assessed Through Combined Opto‐Biomechatronics

open access: yesAdvanced Science, EarlyView.
Combined structure‐function assessment in aortic rings from Marfan mice using MechaMorph Opto‐Biomechatronics technology relates increased elasticity (stiffness) and dynamic viscosity and less ordered extracellular matrix 3D‐structure (collagen) as potential causes for impaired Windkessel function and compromised haemodynamics in Marfan's syndrome ...
Dominik Schneidereit   +10 more
wiley   +1 more source

Hemodialysis Effect on Systolic Left Ventricular Function in Stage V Chronic Kidney Disease Patients [PDF]

open access: yes, 2018
Chronic kidney diasease (CKD) is one of world health problem with increased incidence. Kidney function impairment contribute to cardiovascular complication that has been the main cause of CKD patient death.
Ramadhan, Hazbina Fauqi   +3 more
core   +1 more source

Gut Microbiota‐Derived Indole‐3‐Propionic Acid Alleviates Diabetic Osteoporosis Through Nrf2‐Mediated Ferroptosis Suppression

open access: yesAdvanced Science, EarlyView.
Diabetes‐associated dysbiosis is accompanied by reduced Clostridium abundance, impaired microbial tryptophan metabolism, and lower circulating indole‐3‐propionic acid (IPA). Exogenous IPA improves trabecular microarchitecture and bone formation and restores Nrf2‐associated antioxidant signaling in bone marrow mesenchymal stem cells, limiting iron ...
Jinwu Bai   +12 more
wiley   +1 more source

Myocardial systolic function increases during positive pressure lung inflation.

open access: yes, 2005
Lung inflation with positive airway pressure may have rapid and dynamic effects on myocardial contractile function. We designed this study to assess the magnitude and time to onset of myocardial function changes during the initiation of single positive ...
Häggmark, Sören   +4 more
core   +3 more sources

COMPARATIVE ANALYSIS OF LEFT VENTRICULAR VOLUME PARAMETERS BY VISUALISATION METHOD IN PATIENTS WITH MYOCARDIAL INFARCTION

open access: yesРоссийский кардиологический журнал, 2012
Aim. To investigate the parameters of systolic function in patients with acute Q-wave myocardial infarction (AMI), comparing the results of two-dimensional echocardiography (2D EchoCG), three-dimensional real-time EchoCG (3D EchoCG), and computed ...
N. A. Yaroshchuk   +2 more
doaj  

Systolic algorithms for B-spline patch generation

open access: yes, 1991
A systolic array for constructing the blending functions of B-spline curves and surfaces is described and shown to be 7k times faster than the equivalent sequential computation.
Megson, G.M.
core   +1 more source

Proteogenomic Profiling of Idiopathic Pulmonary Arterial Hypertension Identifies Sex‐Differential Proteins and Candidate Therapeutic Targets

open access: yesAdvanced Science, EarlyView.
An integrated proteogenomic analysis of 44,137 predominantly European‐ancestry UK Biobank participants aged 40–69 years identifies 12 robust proteins associated with idiopathic pulmonary arterial hypertension. These proteins define a high‐mortality molecular endotype, support early detection and mortality prediction, reveal sex‐differential proteomic ...
Xinjie Lin   +18 more
wiley   +1 more source

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