Results 101 to 110 of about 29,765 (194)

Oxidative Stress Drives Cell Cycle Stalling, Apoptosis and Metabolic Suppression in Cystatin B Deficient EPM1 Patient iPSCs

Cell Proliferation, EarlyView.
CSTB deficient EPM1 iPS cells manifest increased lysosomal activity and oxidative stress, which lead to DNA damage, cell cycle defects and increased apoptosis. As a protective response, metabolism is suppressed. Image created by BioRender https://BioRender.com/t44oc6h.
Shekhar Singh, Lidiia Plotnikova, Teemu Tiukuvaara, Reetta Kälviäinen, Riikka H. Hämäläinen   +4 more
wiley   +1 more source

Stimuli-responsive hybrid nanocarriers developed by controllable integration of hyperbranched PEI with mesoporous silica nanoparticles for sustained intracellular siRNA delivery

International Journal of Nanomedicine, 2016
Neeraj Prabhakar,1,2 Jixi Zhang,3 Diti Desai,1 Eudald Casals,1 Tina Gulin-Sarfraz,1 Tuomas Näreoja,2,4 Jukka Westermarck,5,6 Jessica M Rosenholm1 1Pharmaceutical Sciences Laboratory, Faculty of Science and Engineering, Åbo Akademi University,
Prabhakar N, Zhang J, Desai D, Casals E, Gulin-Sarfraz T, Näreoja T, Westermarck J, Rosenholm JM   +7 more
doaj  

Clinical and genetic characterization of intellectual disability

Developmental Medicine &Child Neurology, EarlyView.
This study examines the etiological factors and comorbidities in a large cohort of Finnish patients with intellectual disability. Genetic causes—including chromosomal abnormalities and pathogenic gene variants—were more frequently identified in individuals with moderate to profound intellectual disability.
Aarni Venetvaara, Minna Kraatari‐Tiri, Jussi‐Pekka Tolonen, Marko Merikukka, IDGEN Study Group, Hannaleena Kokkonen, Teija Paakkola, Susanna Varis, Antti Dahl, Jarmo Körkkö, Jonna Komulainen‐Ebrahim, Jukka Moilanen, Johanna Uusimaa, Outi Kuismin, Elisa Rahikkala   +14 more
wiley   +1 more source

Correction: Osteosarcopenia in Finland: prevalence and associated factors. [PDF]

Arch Osteoporos
Blomqvist M, Nuotio M, Sääksjärvi K, Koskinen S, Stenholm S.   +4 more
europepmc   +1 more source

Temperature elevation broadens the dietary niche of an insect herbivore

Ecological Entomology, EarlyView.
The realised dietary niche in Chrysomela lapponica was the narrowest at 10°C, whereas higher temperatures (15–25°C) broadened the dietary niche by increasing preference for and survival on suboptimal host plants. Elevated temperature broadened the realised dietary niche through both direct effects on beetles and indirect effects mediated by temperature‐
Elena L. Zvereva, Vitali Zverev, Mikhail V. Kozlov   +2 more
wiley   +1 more source

Correction to: Exercise training partly ameliorates cardiac dysfunction in mice during doxorubicin treatment of breast cancer. [PDF]

J Transl Med
Uurasmaa TM, Bourdin P, Nammas W, Latifi S, Liljenbäck H, Saraste A, Eskola O, Rajander J, Roivainen A, Rundqvist H, Autio A, Heinonen I, Anttila K.   +12 more
europepmc   +1 more source

Fracture load and three‐dimensional internal void analysis of direct composites used to restore worn molars

European Journal of Oral Sciences, EarlyView.
Abstract This study evaluated (1) the load‐bearing capacity of molars restored with direct occlusal veneers fabricated either from short‐fiber‐reinforced composite (SFRC) or particulate‐filled composite (PFC) and the presence of internal voids within the materials, and (2) effect of water storage on the fracture load and correlation between internal ...
Topias Yli‐Urpo, Jorma Määttä, Auli Suominen, Pekka K. Vallittu, Timo Närhi, Anna‐Maria Le Bell‐Rönnlöf, Jasmina Bijelic‐Donova   +6 more
wiley   +1 more source

Dental resin composites generate microparticles and impact on gingival keratinocytes—In vitro study

European Journal of Oral Sciences, EarlyView.
Abstract Along with our increased understanding of the spread of microplastic pollution, the awareness of microparticle release from medical and dental materials has increased. Still, their effects on human health are largely unknown. As the use of resin composite materials in dentistry continues to increase, it is essential to understand the formation
Ella Pullinen, Saara V. Sirkiä, Johan Nyman, Pekka K. Vallittu, Vuokko Loimaranta   +4 more
wiley   +1 more source

GWAS of Second‐Generation Antihistamine Use: Locus Specificity and Highlighted Signalling Pathways

Clinical &Experimental Allergy, EarlyView.
M. Niemi, S. Ruotsalainen, E. Saarentaus, I. Vähätalo, F. FinnGen, I. Starskaia, T. Harju, M. Pelkonen, T. Feuth, P. Kauppi, J. Partanen, R. Lahesmaa, V. Hytönen, A. Palotie, H. Kankaanranta, T. Laitinen   +15 more
wiley   +1 more source

Defining the role of αC helix interactions in the activation of the integrin αI domain

The FEBS Journal, EarlyView.
The α2I domain of the α2β1 integrin contains a distinctive αC helix and a conserved Arg288‐Glu318 ion pair that stabilizes the closed state of the domain. Disruption of this ion pair in the activated α2I variant unwinds the αC helix, which allows interaction with additional collagen‐binding sites increasing collagen binding.
Liisa Pösö, Tomi T. Airenne, Jarmo Käpylä, Hongmin Tu, Eva Bligt‐Lindén, Vimal Parkash, Jyrki Heino, Tiina A. Salminen   +7 more
wiley   +1 more source