Results 161 to 170 of about 1,424 (205)

Sodium butyrate ameliorates renal tubular lipid accumulation through a protein phosphatase 2A/transcription factor EB axis in diabetic nephropathy

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Extensive evidence indicates that lipid accumulation causes renal tubular injury, which further contributes to diabetic nephropathy (DN) progression. Short‐chain fatty acids (SCFAs) play an important role in the maintenance of cellular metabolic health.
Jiayin Tao, Sinan Ai, Yaoxian Wang, Yuning Liu, Jingwei Zhou, Qingqing Liu, Xu Wang, Danting Li, Xin Li, Lin Wang, Jinyi Hou, Liang Peng, Zhen Wang   +12 more
wiley   +1 more source

Pharmacological inhibition of hydroxysteroid 11‐beta dehydrogenase type 1 (11‐βHSD1) after myocardial infarction preserves cardiac function in a translational mini‐pig model

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Plasma glucocorticoids increase acutely after MI, thereafter tissue levels are amplified selectively within cells expressing 11‐ßhydroxysteroid dehydrogenase type 1 (11‐ßHSD1) that regenerates active glucocorticoids from circulating metabolites.
Sara Al Disi, Raimondo Ascione, Shazia Khan, Thomas Johnson, Eva Sammut, Vito Domenico Bruno, Daniel Baz Lopez, Carol‐Anne James, Joanna Simpson, Natalie Z. Homer, Michael Millar, Trisha Singh, Alex von Kreigsheim, Nick L. Mills, Brian R. Walker, Ruth Andrew, Scott P. Webster, Andrew Whittaker, Adrian Freeman, Gillian A. Gray   +19 more
wiley   +1 more source

A Study on the Mechanism of the Impact of Failed Learning on Enterprise Innovation Performance From the Perspective of Social Information Processing

Creativity and Innovation Management, EarlyView.
ABSTRACT This study investigates the impact mechanism of different dimensions of failure learning on corporate innovation performance. Compared with the extensively researched field in the effects of organizational failure learning, this area remains largely underexplored.
Shiyuan Zhou, Yichao Si
wiley   +1 more source

Exploring children's experiences of schooling in Tanzania: How the ‘hidden curriculum’ undermines aspirations for sustainable development

Children &Society, EarlyView.
Abstract In the context of aspirations that firmly position education as the key to multiple global development goals, we raise concerns about how education is experienced by many children, particularly in low‐income, postcolonial contexts. Drawing from two, in‐depth qualitative studies in Tanzania, we demonstrate that existing pedagogical practices ...
Laela Adamson, Rhona Brown
wiley   +1 more source

Stage‐Associated Microglial Subpopulations and Dynamics in Vascular Pathogenesis of Oxygen‐Induced Retinopathy

Cell Proliferation, EarlyView.
In the oxygen‐induced retinopathy (OIR) mouse model, two distinct microglial subpopulations play opposing roles: highly glycolytic microglia (HGM) promote neovascular formation via Pkm2, while Mrc1/CD206‐positive phagocytosis‐associated microglia (PAM) facilitate its regression.
Yuan Ma, Ziye Chen, Baoyi Liu, Wen Ding, Runping Duan, Kangjie Kong, Zhuojun Xu, Jizhu Li, Jiali Ru, Dianlei Guo, Xiaoyue Wei, Yaping Liu, Zhuangling Lin, Yang Meng, Yuan Liu, Lan Jiang, Zitong Chen, Rebiya Tuxun, Chinling Tsai, Chunqiao Liu, Tao Li   +20 more
wiley   +1 more source

Inositol and Berberine Synergistically Reprogram Endocrine and Ovarian Metabolism in Polycystic Ovary Syndrome

Cell Proliferation, EarlyView.
In a DHEA+HFD‐induced mouse model, Ins/BBR alleviated mitochondrial defects and broadly reprogrammed metabolic landscape in granulosa cells, in specific, restoring nucleotide pools and amino acid turnover, and preventing abnormal long‐chain fatty acid accumulation.
Juan Ge, Chenxiang Zhang, Yilong Zhao, Haiyang Zhao, Shuai Zhu, Tao Tang, Guorui Zhang, Qiang Wang, Hui Wang   +8 more
wiley   +1 more source

Heat Stress Triggers Nuclear Invagination and Spatial Compartmentalization of Protein Metabolism

Cell Proliferation, EarlyView.
Cells adapt heat stress to shape a nuclear invagination region function as “protein metabolism hotspots”, where both protein production and degradation are enhanced. ABSTRACT Heat stress is a common challenge for cells, causing multiple types of cellular damage while triggering complex stress responses, including the highly conserved mechanism known as
Zhi‐Hao Zhang, Yuan‐Tao Qiu, Jing‐Yue Cao, Yi‐Feng Huang, Ye‐Lin Lan, Yu‐Li Zhao, Fu Wu, Chen‐Long Wang, Guo‐Run Tang, Jing‐Yun Ji, Zhang Zhang, Guan‐Zheng Luo   +11 more
wiley   +1 more source

Multinational enterprises’ contribution to gender equality: An integrative framework

International Journal of Management Reviews, EarlyView.
Abstract Despite the progress made in recent years, inequalities between men and women persist. Gender equality (GE) is one of the United Nations Sustainable Development Goals (SDG5) that multinational enterprises (MNEs) can contribute most to. This is because SDG5 integrates directly into MNEs’ human resource practices, supply chain management and ...
Sonia María Suárez‐Ortega, Mar Suarez, Cristina López‐Duarte   +2 more
wiley   +1 more source

Serum CTRP3 and CysC correlate with glucose, lipid, and bone metabolism in elderly patients with type 2 diabetes mellitus complicated with osteoporosis

Journal of Diabetes Investigation, EarlyView.
Serum levels of CTRP3 and CysC in elderly patients with T2DM and OP are closely associated with glucose‐lipid metabolism, bone mineral density, and bone metabolism markers. Combined detection of these two markers can assist in distinguishing OP in elderly patients with T2DM.
Yi‐Peng Wang, Yong Wang, Tao Chen, Gang Chen, Ze‐Yu Yang   +4 more
wiley   +1 more source

Electron microscopy‐based three‐dimensional subcellular imaging of plant male gametophyte

Journal of Integrative Plant Biology, EarlyView.
The Aquilos2 Cryo‐FIB workflows provide practical routes for cryo‐electron tomography and volume imaging in plant structural biology. ABSTRACT Understanding cellular events in three dimensions (3D) is of great importance for the annotation and illustration of biological processes in a contextual way. Imaging techniques based on electron microscopy (EM),
Zhiqi Liu, Zizhen Liang, Mengfei Liao, Yixin Huang, Rui Ma, Jiayang Gao, Weiqi Wang, Tao Ni, Philipp S. Erdmann, Liwen Jiang   +9 more
wiley   +1 more source