MedComm, Volume 7, Issue 9, September 2026.Based on meta‐analyses and cumulative epidemiological evidence, the present study identifies 11 genetic variants in 11 genes that are truly associated with the risk of hepatocellular carcinoma. Our work presents a systematic synopsis, which helps elucidate the mechanisms of carcinogenesis and provides insights into the early diagnosis and novel ...
Yujin Shi +17 more
wiley +1 more source
ACY-1215 and bortezomib cooperatively disrupt NOTCH3 signaling and induce anti-tumor effects in T-ALL models. [PDF]
Biomark ResAngi E +9 more
europepmc +1 more source
RNA‐Binding Proteins: Function, Biological Mechanisms, and Therapeutic Opportunities
MedComm, Volume 7, Issue 9, September 2026.RNA‐binding proteins (RBPs) regulate RNA stability, localization, translation, and splicing through intrinsic binding domains and interactions with diverse cellular partners. Their competitive and cooperative networks shape disease‐related RNA programs, especially in cancer.
Ling Li, Xiuli Yan, Qing Ji, Hui Zhang
wiley +1 more source
Post-translational modifications of triosephosphate isomerase reveal metabolic vulnerabilities in T-ALL: effect of combining dichloroacetic acid and the PPI rabeprazole. [PDF]
Biochem JMartínez-Pérez Y +12 more
europepmc +1 more source
MedComm – Future Medicine, Volume 5, Issue 3, September 2026.IDH mutation is an important event in hematological malignancies. This review systematically integrates the basic mechanism of IDH mutations and combines it with the clinical translation of related research progress. It also discusses the application strategies of IDH inhibitors and feasible research directions, with the aim of providing a theoretical ...
Jinkun Xu, Haiying Bai, Lijuan Hu
wiley +1 more source
Learning Differential Equations From Numerically Integrated Artificial Neural Networks
Proceedings in Applied Mathematics and Mechanics, Volume 26, Issue 3, September 2026.ABSTRACT For numerical investigation of dynamical systems, the formulation of the corresponding ordinary differential equations (ODE) based on physical principles is usually the first and most crucial step. However, if the underlying physics is not fully understood or the required expert knowledge for modeling is missing, setting up these differential ...
Timo Bielitz, Dieter Bestle
wiley +1 more source
Improved identification of T-ALL paediatric patients with low MRD but poor prognosis using a transcriptional signature. [PDF]
Br J HaematolLahera A +8 more
europepmc +1 more source
Histiocytosis development and clinical variation through the lens of genomics
The Journal of Pathology, Volume 270, Issue 1, Page 23-39, September 2026.Abstract Histiocytic neoplasms are rare haematologic diseases characterised by clonal expansions of cells with a monocyte, macrophage or dendritic cell phenotype. Their clinical manifestations are diverse, ranging from indolent lesions to aggressive systemic disease.
Paul G Kemps +3 more
wiley +1 more source
Preemptive Entry and Technology Diffusion: The Market for Drive‐In Theaters
The RAND Journal of Economics, Volume 57, Issue 3, Page 471-494, Autumn (Fall) 2026.ABSTRACT This article studies entry preemption in new industries. We first test a key prediction of dynamic entry games: Entry preemption is most relevant in intermediate‐sized markets, where firms face highest uncertainty about future entry. Using US drive‐in theater market (1945–1957) data, we find robust evidence for this non‐monotonic relationship ...
Ricard Gil +3 more
wiley +1 more source
Transcriptional profiling directs the classification of acute leukemias of ambiguous lineage into AML, B-ALL, or T-ALL. [PDF]
HemasphereMulet-Lazaro R +17 more
europepmc +1 more source