Results 261 to 270 of about 30,760,761 (278)

Carma1 Is Important for T-ALL CNS Infiltration and Survival in an Animal Model of T-ALL

Blood, 2014
Abstract Acute lymphoblastic leukemia (ALL) is one of the most common childhood cancer, and can arise from the T or B cell lineage (T-ALL or B-ALL respectively). T-ALL patients have almost 80% cure rate, however leukemic cell migration to the central nervous system (CNS) remains a major therapeutic challenge.
Sreenivasa Rao Oruganti, Christina Halsey, Savannah Krebsbach, Francois Asperti-Boursin, Sumit Patel, Ksenia Matlawska-Wasowska, Stuart S. Winter, Judy Cannon   +7 more
openaire   +1 more source

Immunogenicity of Childhood T-ALL.

Blood, 2006
Abstract Background: Acute lymphoblastic leukemia (ALL) with a T cell immunophenotype accounts for about 15% of childhood ALL. While contemporary treatment protocols have improved the relapse free survival for children with T-ALL, it has for a long time been considered a malignancy with a dismal prognosis.
Renate Panzer-Grümayer, Andrea Inthal, Gerd Krapf, Thomas Felzmann, Helmut Gadner, Alexander Dohnal   +5 more
openaire   +1 more source

Immunophenotype and function define TCRγδ + T-ALL as a distinct subgroup from TCRαβ + T-ALL patients

Leukemia & Lymphoma, 2019
We recently demonstrated TCRγδ + T-ALL as a distinct subgroup from TCRαβ + T-ALL at genomic level. TCRγδ + T-ALL subgroup possess significant survival advantage compared to TCRαβ + T-ALL. In the present study, functional level differences in these two subgroups of T-ALL were studied to understand the immune scenario contributing to survival benefit of ...
Gauri, Mirji, Shripad, Banavali, Manju, Sengar, Shubhada V, Chiplunkar   +3 more
openaire   +2 more sources

Characteristics of pro-T ALL subgroups: Comparison with late T-ALL

1993
info:eu-repo/semantics ...
Garand, Richard, Voisin, Sabine, Papin, Sophie, Praloran, Vincent, Lenormand, Bernard, Favre, Mireille, Philip, Patrick Jean Marie P., Bernier, Michel, Vanhaecke, D., Falkenrodt, Annie, Béné, Marie-Christine, Faure, Gilbert   +11 more
openaire   +1 more source

Activating TCR Signaling to Thwart T-ALL

Cancer Discovery, 2016
Abstract Summary: Thymic negative selection is a process that aims to eliminate autoreactive T cells by inducing the apoptosis of thymocytes expressing a T-cell receptor (TCR) with high affinity for self-MHC. In this issue, Trinquand and colleagues demonstrate that TCR engagement or anti-CD3 stimulation of TCR-expressing T acute ...
François, Lemonnier, Tak W, Mak
openaire   +2 more sources

Recent Advances on NOTCH Signaling in T-ALL

2012
NOTCH1 receptor signaling plays a central role in T-cell lineage specification and in supporting the growth and proliferation of immature T-cell progenitors in the thymus during lymphoid development. In T-cell acute lymphoblastic leukemia (T-ALL), a tumor resulting from the malignant transformation of T-cell progenitors, aberrant and constitutively ...
Gannie, Tzoneva, Adolfo A, Ferrando
openaire   +2 more sources

It Isn t All Fieldwork!

2012
This resource is a single blog post created as part of the Day of Archaeology initiative. The Day of Archaeology project aimed to provide a window into the daily lives of archaeologists from all over the world. The project asked people working, studying or volunteering in the archaeological world to participate in a 'Day of Archaeology' each year by ...
openaire   +1 more source

Avoiding fratricide: a T-ALL order

Blood, 2022
Mark Gower, Anastasia N. Tikhonova
openaire   +2 more sources

A T-ALL order: a new risk classifier for T-ALL

Blood
Haley Newman, David T. Teachey
openaire   +2 more sources

NUP214–ABL1 fusion in childhood T‐ALL

Pediatric Blood & Cancer, 2022
Veltri, Giulia, Sandei, Max, Silvestri, Daniela, Bresolin, Silvia, Pession, Andrea, Santoro, Nicola, Ziino, Ottavio, Veltroni, Marinella, Rizzari, Carmelo, Biffi, Alessandra, Valsecchi, Maria Grazia, Conter, Valentino, Buldini, Barbara, Accordi, Benedetta, Serafin, Valentina   +14 more
openaire   +5 more sources