Results 131 to 140 of about 2,055,767 (301)

Macrophage-independent T cell infiltration to the site of injury-induced brain inflammation

, 2008
We have addressed the role of macrophages in glial response and T cell entry to the CNS after axonal injury, by using intravenous injection of clodronate-loaded mannosylated liposomes, in C57BL6 mice.
Owens, T, Fux, Michaela, Fux, M., Owens, Trevor; id_orcid, Owens, Trevor, Michaela Fux, van Rooijen, Nico, van Rooijen, N., Nico van Rooijen, Trevor Owens   +9 more
core   +1 more source

In vitro and in vivo depletion of T cells.

Bone marrow transplantation, 1994
Transplant related mortality and relapse after bmt have a negative influence on the outcome of patients transplanted for acute leukaemia in first remission. Transplant related mortality includes graft-versus-host disease, infections and graft failure. To prevent gvhd and associated infections without increased graft rejection, a protocol of combined in
Arnold, R, Bunjes, D, Wiesneth, M, Hertenstein, B, Theobald, M, Heimpel, H, Hale, G, Waldmann, H   +7 more
openaire   +2 more sources

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Transcriptomic profiling after B cell depletion reveals central and peripheral immune cell changes in multiple sclerosis

The Journal of Clinical Investigation
Multiple sclerosis (MS) is a complex, genetically mediated autoimmune disease of the CNS, in which anti-CD20–mediated B cell depletion is remarkably effective in the treatment of early disease.
Jessica Wei, Jeonghyeon Moon, Yoshiaki Yasumizu, Le Zhang, Khadir Radassi, Nicholas Buitrago-Pocasangre, M. Elizabeth Deerhake, Nicolas Strauli, Chun-Wei Chen, Ann Herman, Rosetta Pedotti, Catarina Raposo, Isaiah Yim, Jenna Pappalardo, Erin E. Longbrake, Tomokazu S. Sumida, Pierre-Paul Axisa, David A. Hafler   +17 more
doaj   +1 more source

CD8 T cells promote heart failure progression in mice with preexisting left ventricular dysfunction

Frontiers in Immunology
IntroductionEven under the standard medical care, patients with left ventricular (LV) failure or heart failure (HF) often progress to pulmonary hypertension and right ventricular (RV) hypertrophy.
Dongzhi Wang, Dongzhi Wang, Xinyu Weng, Xinyu Weng, Wenhui Yue, Linlin Shang, Linlin Shang, Yidong Wei, John S. Clemmer, Yawei Xu, Yingjie Chen, Yingjie Chen   +11 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

ATP-gated ionotropic P2X7 receptor controls follicular T helper cell numbers in Peyer's patches to promote host-microbiota mutualism.

, 2014
Microbial colonization of the gut induces the development of gut-associated lymphoid tissue (GALT). The molecular mechanisms that regulate GALT function and result in gut-commensal homeostasis are poorly defined.
Grassi, Fabio, Radaelli, E, Proietti, Michele, K. McCoy, Traggiai, Elisabetta, Preziuso, Silvia, Caprioli, F, F. Caprioli, Slack, Emma, McCoy, Kathleen, F. Grassi, C. Faliti, Brannetti, B, RezzonicoJost, T, S. Preziuso, Perruzza, Lisa, E. Traggiai, Slack, E, M. Thelen, Brannetti, Barbara, Rigoni, R, Faliti, Caterina Elisa, Preziuso, S, Thelen, Marcus, L. Perruzza, Romagnani, A, Rigoni, Rosita, Caprioli, Flavio, E. Radaelli, B. Brannetti, Radaelli, Enrico, M. Proietti, McCoy, KD, Cornacchione, Vanessa, Faliti, CE, V. Cornacchione, Traggiai, E, Rezzonico Jost, Tanja, Grassi, F, Thelen, M, A. Romagnani, Perruzza, L, T. Rezzonico Jost, Cornacchione, V, R. Rigoni, McCoy, Kathy D., E. Slack, Proietti, M, Romagnani, Andrea   +48 more
core   +1 more source

Graft versus host disease in a rat small bowel transplant model after T-cell depleted donor specific bone marrow infusion

Acta Cirúrgica Brasileira, 2003
Low cytoreductive regimen of irradiation associated to unmodified bone marrow infusion (UBM) does not prevent the occurrence of graft versus host disease (GVHD) after transplant. PURPOSE: In this study we evaluated the potential advantages of a long-term
Bakonyi Neto Alexandre, Misiakos Evangelos P., Tzakis Andreas G., Behro Mariana, Ruiz Phillip, Miller Joshua, Ricordi Camilo, Takegawa Bonifacio K.   +7 more
doaj  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Constraints on the CD8 T cell response in chronic HBV infection [PDF]

, 2009
The inflamed liver in chronic hepatitis B virus infection (CHB) is characterised by a large influx of non-virus specific CD8 T cells, which we hypothesize could provide insights into mechanisms of failure of viral control and liver damage in this setting.
Das, A., Das, A
core