Results 101 to 110 of about 2,269,258 (384)
Simultaneous inhibition of pan-phosphatidylinositol-3-kinases and MEK as a potential therapeutic strategy in peripheral T-cell lymphomas [PDF]
, 2013 Obtained from Haematologica/the Hematology Journal website http://www.haematologica.orgPeripheral T-cell lymphomas are very aggressive hematologic malignancies for which there is no targeted therapy. New, rational approaches are necessary to improve the
Bischoff, James R. +19 more
core +2 more sources
Molecular Oncology, EarlyView.This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti +10 more
wiley +1 more source
Acta Dermato-Venereologica, 2020 Mycosis fungoides and Sézary syndrome belong to the group of primary cutaneous T-cell lymphomas. Because of the inflammatory appearance of the skin lesions, we hypothesized that antimicrobial peptides might be dysregulated in these conditions, similar to
Ulrike Wehkamp +3 more
doaj +1 more source
Targeting CD38 in Refractory Extranodal Natural Killer Cell-T-Cell Lymphoma.
New England Journal of Medicine, 2016 Extranodal natural killer cell–T-cell lymphoma is a highly aggressive Epstein–Barr virus–related cancer. A woman with recurrent disease after many courses of therapy, including allogeneic hematopoietic-cell transplantation, had a complete response to ...
P. Hari, Renju V. Raj, H. Olteanu
semanticscholar +1 more source
Molecular Oncology, EarlyView.Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu +11 more
wiley +1 more source
Therapeutic Efficacy of Etretinate on Cutaneous-type Adult T-cell Leukemia-Lymphoma
Acta Dermato-Venereologica, 2019 Cutaneous-type adult T-cell leukemia-lymphoma is treated with antiviral or skin-directed therapy. Medications that are used to treat skin lesions of cutaneous T-cell lymphomas are also used for the cutaneous-type adult T-cell leukemia-lymphoma ...
Kentaro Yonekura +5 more
doaj +1 more source
Haematologica, 2013 A characteristic feature of anaplastic large cell lymphoma is the significant repression of the T-cell expression program despite its T-cell origin. The reasons for this down-regulation of T-cell phenotype are still unknown.
Maria Joosten +8 more
doaj +1 more source
Enteropathy Associated T Cell Lymphoma – A Case Report of An Uncommon Extranodal T Cell Lymphoma [PDF]
Journal of Clinical and Diagnostic Research, 2014 Enteropathy associated T cell lymphoma is a rare primary intestinal lymphoma. It is often, but not always associated with celiac disease. Intraepithelial T cells are postulated as the cell of origin.
Geetha V +2 more
doaj +1 more source
Frequent CTLA4-CD28 gene fusion in diverse types of T-cell lymphoma
Haematologica, 2016 CTLA4 and CD28 are co-regulatory receptors with opposite roles in T-cell signaling. By RNA sequencing, we identified a fusion between the two genes from partial gene duplication in a case of angioimmunoblastic T-cell lymphoma.
H. Yoo +11 more
semanticscholar +1 more source
Dermatology Online Journal, 2005 A 32-year-old man presented with a 5-year history of cutaneous nodules on his head and a diffuse, lichenified eruption. Histopathologic examination showed an atypical lymphocytic infiltrate. Immunophenotyping studies determined that the lymphocyte population to be CD4-positive, with partial loss of CD3 and CD7, and immunogenotyping studies showed a ...
openaire +4 more sources