Results 131 to 140 of about 2,045,259 (260)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Activation of OsOxO2 by T-DNA Insertion Affects Plant Height and Leaf Angle in Rice. [PDF]

Rice (N Y)
Hu XW, Wang HY, Yu XL, Leung DWM, Chen YL, Chen DH, Chen K, Peng XX, Liu EE.   +8 more
europepmc   +1 more source

The Arabidopsis T-DNA mutant SALK_008491 carries a 14-kb deletion on chromosome 3 that provides rare insights into the plant response to dynamic light stress. [PDF]

Plant Direct, 2022
Lopez LS, Völkner C, Day PM, Lewis CM, Lewis CL, Schneider D, Correa Galvis V, Cruz JA, Armbruster U, Kramer DM, Kunz HH.   +10 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Versatile Applications of CRISPR-Based Programmable T-DNA Integration in Plants. [PDF]

Plant Biotechnol J
Lin XX, Gong BQ, Wang FZ, Wan JB, Xiong X, Li JF.   +5 more
europepmc   +1 more source

slim shady is a novel allele of PHYTOCHROME B present in the T-DNA line SALK_015201. [PDF]

Plant Direct, 2021
Dash L, McEwan RE, Montes C, Mejia L, Walley JW, Dilkes BP, Kelley DR.   +6 more
europepmc   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Correction: Analysis of T-DNA alleles of flavonoid biosynthesis genes in Arabidopsis ecotype Columbia. [PDF]

BMC Res Notes
Bowerman PA, Ramirez MV, Price MB, Helm RF, Winkel BSJ.   +4 more
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

SeedSeg: image-based transgenic seed counting for segregation analysis of T-DNA loci. [PDF]

Plant Methods
Hernández S, Zhong V, Brophy JAN.
europepmc   +1 more source