Results 151 to 160 of about 7,881,676 (290)

Optimization of hydrofoil leading-edge geometry for delaying incipient cavitation using a CFD-GA approach. [PDF]

Sci Prog
Xie X, Tao R, Tao R.
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Effect of biodegradable magnesium foil as an anti-adhesion barrier on the healing of rat Achilles tendon. [PDF]

Front Bioeng Biotechnol
Xue X, Han T, Yan K, Dai J, Wang T, Wang J, Gu J.   +6 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

The Interstellar Mapping And Acceleration Probe High Energy (IMAP-Hi) Neutral Atom Imager. [PDF]

Space Sci Rev
Funsten HO, Allegrini F, Reisenfeld DB, Cardarelli G, Carpenter BC, Christian ER, Cortinas S, Craft SP, Da Rocha FD, Dauson ER, De Los Santos A, Dunn GF, Fernandes PA, Fletcher G, Ford KA, Ford J, Geros EG, Gkioulidou M, Grubbs G, Guthrie AA, Hanley JJ, Harvey DS, Hemphill RL, Hill BD, Hoeper PJ, Hom-Crosier RD, Hooks DE, Janzen PH, Kim TK, Lanctot SI, Liu Y, Maldonado CA, Martinez JP, McComas DJ, Merrill AS, Moebius E, Moorhead-Rosenberg Z, Mosley BNT, Newell RT, Noh S, Nunez C, Pacheco TR, Pontoni AA, Pope SE, Rahmanifard F, Rodriguez BG, Rodriguez H, Sandoval BF, Schultz TB, Schiferl CM, Schwadron NA, Skoug RM, Storms SA, Tapley MB, Taylor KL, Taylor TW, Toczynski W, Trevino JA, Tucker CJ, Venhaus DM, Vigil VJ, Walia NK, Wurz P.   +62 more
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Numerical investigation of wake interaction and bio-inspired propulsive performance of tandem flapping foils for soft-robotic underwater locomotion. [PDF]

Sci Rep
Swain PK, Padhi SN, Raj A N, Kalam SA, Choudhury M, Raghuram KS, Rafighi M, Sharma P.   +7 more
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Accurate alpha-particle stopping power measurements in graphenic carbon foils and their application to high-precision, non-destructive areal density determination. [PDF]

Sci Rep
Botsiou K, Purushothaman S, Geissel H, Dickel T, Enders J, Haettner E, Morrissey DJ, Saifulin M, Scheidenberger C, Tomut M, Weick H, Zhao J.   +11 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source