Results 31 to 40 of about 132,916 (265)

Aberrant Alteration of Circulating Lymphocyte Subsets in Small Cell Lung Cancer Patients Treated with Radiotherapy

Technology in Cancer Research & Treatment, 2021
Purpose: The role of different circulating lymphocyte subsets, as well as their correlation with clinical characteristics of small cell lung cancer patients have not yet been fully understood.
Hui Li MD, Hong Yu MM, Shaowei Lan MD, Dandan Zhao MB, Yan Liu MM, Ying Cheng MB   +5 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Peripheral blood lymphocyte subsets of Chinese adults with liver steatosis

Scientific Reports
To evaluate the effect of liver steatosis on systematic cellular immunity through the changes of peripheral blood lymphocyte subsets, we retrospectively reviewed subjects receiving lymphocyte subtyping during annual medical check-ups. Liver steatosis was
Xiaxiao Yan, Jing Li, Qiang Wang, Tengda Xu, Dong Wu   +4 more
doaj   +1 more source

Peripheral blood T-cell subsets combined with EGRIS score predict the need for mechanical ventilation in Guillain–Barré syndrome

Frontiers in Immunology
BackgroundThe pathogenesis of Guillain–Barré syndrome (GBS) may involve lymphocyte-mediated immune mechanisms. This study aimed to investigate the relationship between peripheral blood lymphocyte subsets and disease onset, severity, and the need for ...
Feihong Jia, Xinrui Wang, Yuan Chen, Yunshu Li, Xinshu Du, Hongping Chen, Di Zhong   +6 more
doaj   +1 more source

Investigation of Lymphocyte Subsets in Peripheral Blood of Patients with Dyslipidemia

International Journal of General Medicine, 2021
Da-Ming Xu,1,* Qian Li,2,* Jing-Xing Yi,3,* Xin-Jian Cai,3 Long Xie,3 Wei Fang,3 Jin-Feng Qiu,4 Cheng-Wei Xu,5 Chun-Ling He,6 Xian-Ru Xu,7 Jie-Song Xu,8 Jun Yin2,3 1Division of Urological Surgery, Second Affiliated Hospital of Shantou ...
Xu DM, Li Q, Yi JX, Cai XJ, Xie L, Fang W, Qiu JF, Xu CW, He CL, Xu XR, Xu JS, Yin J   +11 more
doaj  

Comparison of low density lipoprotein uptake by different human lymphocyte subsets: a new method using double-fluorescence staining.

Journal of Lipid Research, 1996
A method to determine low density lipoprotein (LDL) uptake of distinct lymphocyte subpopulations was developed using fluorescent LDL and subsequent staining of lymphocyte subsets with biotinylated monoclonal antibodies plus streptavidin-CyChrome.
C Maczek, H Recheis, G Böck, T Stulnig, G Jürgens, G Wick   +5 more
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Nuclear receptor corepressor 1 controls regulatory T cell subset differentiation and effector function

eLife
FOXP3+ regulatory T cells (Treg cells) are key for immune homeostasis. Here, we reveal that nuclear receptor corepressor 1 (NCOR1) controls naïve and effector Treg cell states.
Valentina Stolz, Rafael de Freitas e Silva, Ramona Rica, Ci Zhu, Teresa Preglej, Patricia Hamminger, Daniela Hainberger, Marlis Alteneder, Lena Müller, Monika Waldherr, Darina Waltenberger, Anastasiya Hladik, Benedikt Agerer, Michael Schuster, Tobias Frey, Thomas Krausgruber, Sylvia Knapp, Clarissa Campbell, Klaus Schmetterer, Michael Trauner, Andreas Bergthaler, Christoph Bock, Nicole Boucheron, Wilfried Ellmeier   +23 more
doaj   +1 more source