Results 41 to 50 of about 10,492,376 (301)

Skin TLR7 triggering promotes accumulation of respiratory dendritic cells and natural killer cells. [PDF]

, 2012
The TLR7 agonist imiquimod has been used successfully as adjuvant for skin treatment of virus-associated warts and basal cell carcinoma. The effects of skin TLR7 triggering on respiratory leukocyte populations are unknown.
Lohmeyer, Jürgen, Werner von Wulffen (141047), Gruber, Achim D., Gregor Bein (141053), Knoche, Angela, Kershaw, Olivia, Kranz, Sabine, Angela Knoche (141037), Holger Hackstein (141030), Hagel, Nicole, Angela Knoche, Wulffen, Werner von, Olivia Kershaw (141049), Holger Hackstein, Olivia Kershaw, Achim D. Gruber (141051), Nicole Hagel, Gregor Bein, Jürgen Lohmeyer, Sabine Kranz, Nicole Hagel (141033), Baal, Nelli, Bein, Gregor, Achim D Gruber, Jürgen Lohmeyer (141044), Nelli Baal (141055), Hackstein, Holger, Nelli Baal, Werner von Wulffen, Sabine Kranz (141040)   +29 more
core   +2 more sources

Dynamic monitoring of lymphocyte subsets at different disease stages can predict the prognosis of acute myeloid leukemia especially in complete remission status

Scientific Reports
Acute myeloid leukemia (AML) lacks effective prognostic markers. While lymphocyte subsets are recognized as valuable predictive indicators in hematologic malignancies, their role in AML remains largely unexplored, particularly during different stages of ...
Xunyi Jiao, Ji Zhou, Xue Liang, Jinli Zhu, Meng Xiao, Yangyang Ding, Qianshan Tao, Hao Xiao, Yingwei Li, Huiping Wang, Zhimin Zhai   +10 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Nodular lymphocyte predominant hodgkin lymphoma and T cell/histiocyte rich large B cell lymphoma : endpoints of a spectrum of one disease? [PDF]

, 2013
In contrast to the commonly indolent clinical behavior of nodular lymphocyte predominant Hodgkin lymphoma (NLPHL), T cell/histiocyte rich large B cell lymphoma (THRLBCL) is frequently diagnosed in advanced clinical stages and has a poor prognosis ...
Benjamin Rengstl, Sebastian Newrzela, Randy Gascoyne, Xavier Sagaert (482298), Xavier Sagaert, Hartmann, Sylvia, Martin-Leo Hansmann, Claudia Döring, Küppers, Ralf, Chris de Wolf-Peeters, Fabio Facchetti, Ralf Küppers, Fabio Facchetti (376587), Sylvia Hartmann, Rengstl, Benjamin, Hansmann, Martin-Leo, Christian Steidl, Sagaert, Xavier, Martin-Leo Hansmann (260067), Tousseyn, Thomas, Christian Steidl (482300), Ralf Küppers (260072), Thomas Tousseyn (482297), Chris de Wolf-Peeters (482299), Steidl, Christian, Claudia Döring (474984), Ponzoni, Maurilio, Randy Gascoyne (482301), Jakobus, Christina, Wolf-Peeters, Chris de, Benjamin Rengstl (482295), Sebastian Newrzela (482296), Gascoyne, Randy, Maurilio Ponzoni (126480), Döring, Claudia, Thomas Tousseyn, Christina Jakobus (482294), Christina Jakobus, Facchetti, Fabio, Sylvia Hartmann (260069), Newrzela, Sebastian, Maurilio Ponzoni   +41 more
core   +2 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Effect of abrupt weaning at housing on leukocyte distribution, functional activity of neutrophils, and acute phase protein response of beef calves [PDF]

, 2010
peer-reviewedBackground: Sixteen, spring-born, single suckled, castrated male calves of Limousin × Holstein-Friesian and Simmental × Holstein-Friesian dams respectively, were used to investigate the effect of weaning on total leukocyte and differential ...
Lynch EM, McGee, Mark, McGee, M., Lynch, Eilish M, S Doyle, Lynch, E.M., Doyle S, B Earley, M McGee, Doyle, Sean, McGee M, Earley, Bernadette, Earley B, EM Lynch, Earley, B.   +14 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Association of lymphocyte subsets with the efficacy and prognosis of PD‑1 inhibitor therapy in advanced gastric cancer: results from a monocentric retrospective study

BMC Gastroenterology
Purpose This retrospective study aimed to investigate the changes in peripheral blood lymphocyte subsets before and after immunotherapy in patients with advanced gastric cancer and their relationship n with the therapeutic efficacy and clinical prognosis.
Xinyan Wang, Xiaoling Liu, Huwei Dai, Junmei Jia   +3 more
doaj   +1 more source

Age-related impairment of human T lymphocytes' activation: specific differences between CD4+ and CD8+ subsets [PDF]

, 2006
The relevance of physiological immune aging is of great interest with respect to determining disorders with pathologic immune function in aging individuals.
Maurer, Konrad, Schindowski, Katharina, Frölich, Lutz, Eckert, Anne, Müller, Walter E.   +4 more
core  

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source