Results 61 to 70 of about 172,749 (310)

Nuclear receptor corepressor 1 controls regulatory T cell subset differentiation and effector function

eLife
FOXP3+ regulatory T cells (Treg cells) are key for immune homeostasis. Here, we reveal that nuclear receptor corepressor 1 (NCOR1) controls naïve and effector Treg cell states.
Valentina Stolz, Rafael de Freitas e Silva, Ramona Rica, Ci Zhu, Teresa Preglej, Patricia Hamminger, Daniela Hainberger, Marlis Alteneder, Lena Müller, Monika Waldherr, Darina Waltenberger, Anastasiya Hladik, Benedikt Agerer, Michael Schuster, Tobias Frey, Thomas Krausgruber, Sylvia Knapp, Clarissa Campbell, Klaus Schmetterer, Michael Trauner, Andreas Bergthaler, Christoph Bock, Nicole Boucheron, Wilfried Ellmeier   +23 more
doaj   +1 more source

Altered peripheral lymphocyte subsets in untreated systemic lupus erythematosus patients with infections

Brazilian Journal of Medical and Biological Research, 2019
The leading cause of death in systemic lupus erythematosus (SLE) patients is infection. The objective of this study was to evaluate the distribution of lymphocyte subsets in untreated SLE patients with infections. This was a cross-sectional study.
Zhimin Lu, Jing Li, Juan Ji, Zhifeng Gu, Zhanyun Da   +4 more
doaj   +1 more source

Lymphocyte subsets as a predictor of severity and prognosis in COVID-19 patients

International Journal of Immunopathology and Pharmacology, 2021
Background Coronavirus disease 2019 (COVID-19) had become a worldwide health threat. Early prediction of the severity of COVID-19 patients was important for reducing death rate and controlling this disease.
Peng Zhang, Wei Du, Ting Yang, Lei Zhao, Richeng Xiong, Yongqiang Li, Yan Geng, Weizhong Lu, Juan Zhou   +8 more
doaj   +1 more source

Relationship Between Neurologic Symptoms and Signs and FMR1 Genotype in Premutation Carriers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Fragile X‐associated Tremor/Ataxia Syndrome (FXTAS) is the most severe late‐onset condition caused by a premutation in the FMR1 gene, characterized by expanded CGG triplet repeats of 55–200. Clinical presentations of FXTAS, including gait ataxia, kinetic tremor, cognitive decline, and rare Parkinsonism, are linked to ...
Flora Tassone, Freddy Chafota, Miguel E. Rentería, Randi J. Hagerman, Ellery Santos, Anna Atkinson, Nicholas G. Martin, Elsdon Storey, Danuta Z. Loesch   +8 more
wiley   +1 more source

Imbalance of T Lymphocyte Subsets in Adult Immune Thrombocytopenia

International Journal of General Medicine, 2021
Xiuxiu Lin,1 Anhui Xu,1 Li Zhou,1 Na Zhao,1 Xinhui Zhang,2 Jin Xu,3 Shanglong Feng,2 Changcheng Zheng1 1Department of Hematology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China,
Lin X, Xu A, Zhou L, Zhao N, Zhang X, Xu J, Feng S, Zheng C   +7 more
doaj  

Safety and immunogenicity of H1/IC31®, an adjuvanted TB subunit vaccine, in HIV-infected adults with CD4+ lymphocyte counts greater than 350 cells/mm3: a phase II, multi-centre, double-blind, randomized, placebo-controlled trial. [PDF]

, 2014
BACKGROUND: Novel tuberculosis vaccines should be safe, immunogenic, and effective in various population groups, including HIV-infected individuals. In this phase II multi-centre, double-blind, placebo-controlled trial, the safety and immunogenicity of ...
Said, Khadija, Benjamin M Kagina, Willem A Hanekom, Nicole Lenz (671838), Hoff, Søren T., Fielding, Katherine L., Ingrid Kromann (370517), Khadija Said, Hannah Jeffery, Gardiner, Nicolene, Trevor Beattie (671836), Willem A. Hanekom (125097), Daubenberger, Claudia, Klaus Reither, Peter Andersen, Trevor Beattie, Fielding, Katherine L, Scriba, Thomas J, Hoff, Søren T, Søren T. Hoff (246744), Ingrid Kromann, Pohl, Christian, Klaus Reither (259897), Landay, Alan, Katsoulis, Lynn, Lynn Katsoulis, Scriba, Thomas J., Katherine L Fielding, Bang, Peter, Christian Pohl, Peter Bang (671842), Jeffery, Hannah, Peter Bang, Hannah Jeffery (671839), Nicolene Gardiner (671837), Elisabeth J. Hughes (671841), Claudia Daubenberger, Elirehema Mfinanga (476407), Elisabeth J Hughes, Søren T Hoff, Hughes, Elisabeth J., Gavin J. Churchyard (143332), Elirehema Mfinanga, Kagina, Benjamin M, Nicole Lenz, Benjamin M. Kagina (671840), Thomas J Scriba, Khadija Said (476408), Churchyard, Gavin J, Hanekom, Willem A., Mfinanga, Elirehema, Beattie, Trevor, Christian Pohl (476404), Kagina, Benjamin M., Andersen, Peter, Hanekom, Willem A, Reither, Klaus, Nicolene Gardiner, Thomas J. Scriba (76847), Claudia Daubenberger (212658), Lynn Katsoulis (671835), Kromann, Ingrid, Gavin J Churchyard, Hughes, Elisabeth J, Peter Andersen (88335), Churchyard, Gavin J., Lenz, Nicole, Katherine L. Fielding (143336)   +67 more
core   +1 more source

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

Diagnostic Use of Testing for Novel Murine Autoantibodies for Sjögren Disease in the Rheumatology Outpatient Setting

Arthritis Care &Research, EarlyView.
Objective The goal was to assess the diagnostic performance of three novel autoantibodies (NA) for Sjögren disease (SjD) by comparing NA prevalence in patients with SjD, other autoimmune rheumatic diseases (ARDs), nonspecific chronic sialadenitis (CS), and controls.
Chadwick R. Johr, Michael D. George, Vatinee Y. Bunya, Nora Sandorfi, Mina Massaro‐Giordano, Frederick B. Vivino   +5 more
wiley   +1 more source

Effects of Iron Deficiency and Its Indicators on Lymphocyte Subsets: A Study at King Fahd Hospital of the University, Saudi Arabia

Journal of Blood Medicine, 2022
Lolwa AlRajeh,1 Amr Zaher,1 Amal alghamdi,2 Rasha Alsheikh,2 Osama AlSultan3 1Department of Pathology, College of Medicine, Imam Abdulrahman University, Dammam, Saudi Arabia; 2Family and Community Medicine Department, College of Medicine, Imam ...
AlRajeh L, Zaher A, Alghamdi A, Alsheikh R, AlSultan O   +4 more
doaj  

CD4 and CD8 Lymphocyte Counts as Surrogate Early Markers for Progression in SARS-CoV-2 Pneumonia: A Prospective Study

Viruses, 2020
Background: COVID-19 pathophysiology and the predictive factors involved are not fully understood, but lymphocytes dysregulation appears to play a role.
Joan Calvet, Jordi Gratacós, María José Amengual, Maria Llop, Marta Navarro, Amàlia Moreno, Antoni Berenguer-Llergo, Alejandra Serrano, Cristóbal Orellana, Manel Cervantes   +9 more
doaj   +1 more source