Results 31 to 40 of about 54,569 (261)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Lymphocyte subpopulations and neutrophil function in chronic human Chagas' disease Subpopulações linfocitárias e função neutrofílica na doença de Chagas humana

Revista do Instituto de Medicina Tropical de São Paulo, 1990
The absolute numbers of total leukocytes, lymphocytes, T cells, helper/inducer, suppressor/cytotoxic and B cells were decreased in the peripheral blood of patients with chronic Chagas' disease.
J. C. Voltarelli, E. A. Donadi, I. F. Carvalho, R. P. Falcão   +3 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Childhood sarcoidosis: A rare but fascinating disorder

Pediatric Rheumatology Online Journal, 2008
Childhood sarcoidosis is a rare multisystemic granulomatous disorder of unknown etiology. In the pediatric series reported from the southeastern United States, sarcoidosis had a higher incidence among African Americans. Most reported childhood cases have
Gedalia Abraham, Shetty Avinash K
doaj   +1 more source

In vitro studies on T cell proliferation and Lymphokine factor production in the amphibian, Xenopus [PDF]

, 1990
The major aim of this Thesis has been to procure and begin to characterise T cell-derived cytokines in the clawed toad, Xenopus. Recent reports have suggested that Xenopus lymphocytes, stimulated in vitro with T cell mitogens, will generate factors that ...
Turner, Sarah Louise
core  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Alterações radiográficas em pacientes com a co-infecção vírus da imunodeficiência humana/tuberculose: relação com a contagem de células TCD4+ Radiographic alterations in patients presenting human immunodeficiency virus/tuberculosis coinfection: correlation with CD4+ T cell counts

Jornal Brasileiro de Pneumologia, 2006
OBJETIVO: Correlacionar os padrões radiológicos com a contagem de células TCD4+ em pacientes co-infectados por tuberculose e vírus da imunodeficiência humana.
Rosemeri Maurici da Silva, Lígia da Rosa, Renata Nunes Lemos   +2 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Deficiency of T4 epitope expressed on helper/inducer T lymphocytes in 2 osteosarcoma patients and its relation with ras p21 expression in peripheral blood lymphocytes.

Japanese Journal of Oral & Maxillofacial Surgery, 1991
Analysis of peripheral blood lymphocytes (PBL) populations using the OK or Leu series of monoclonal antibodies is commonly conducted to investigate the immunological status of patients such as autoimmune disease, immunodeficiency syndrome, or malignant tumor. We have recently encountered two eases of osteosarcoma with deficiency of T4 epitope on helper/
AZUMA, Masayuki, KAJI, Ryoji, KASAI, Yasuo, KONDO, Yasuo, YOSHIDA, Hideo, SATO, Mitsunobu   +5 more
openaire   +2 more sources