Results 91 to 100 of about 129,740 (272)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
IEEE Access, 2019 The aim of this paper is to develop some novel operational laws for a hesitant fuzzy linguistic term set (HFLTS)-based on the improved supplementary regulation and Archimedean t-norms and s-norms.
Peng Xiao +5 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
The intuitionistic fuzzy multi-criteria decision making based on inclusion degree [PDF]
, 2017 This paper introduces a new intuitionistic fuzzy multicriteria decision making method of evaluation based on degree of inclusion of two intuitionistic fuzzy sets.
Ashraf, Samina +2 more
core +1 more source
Sugeno's negations and t-norms
Mathware & soft computing, 1994 A functional characterization of Sugeno's negations is presented and as a consequence, we study a family of non strict Archimedean t-norms whose (vertical-horizontal) sections are straight lines.
openaire +3 more sources
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Tropical linear algebra with the Łukasiewicz T-norm
Fuzzy Sets and Systems, 2015 The max-Lukasiewicz semiring is defined as the unit interval [0,1] equipped with the arithmetics "a+b"=max(a,b) and "ab"=max(0,a+b-1). Linear algebra over this semiring can be developed in the usual way. We observe that any problem of the max-Lukasiewicz linear algebra can be equivalently formulated as a problem of the tropical (max-plus) linear ...
Gavalec, Martin +2 more
openaire +2 more sources