Results 111 to 120 of about 11,497,059 (304)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Patterns of Inheritance

open access: yes, 2010
This OER consists of an instructional sheet produced by GENIE CETL in the Department of Genetics. By the end of this material you would have learnt about: How traits and characteristics are passed on from one generation to another The different ...
GENIE CETL
core  

Patterns of information security postures for socio-technical systems and systems-of-systems [PDF]

open access: yes, 2012
This paper describes a proposal to develop patterns of security postures for computer based socio-technical systems and systems-of-systems.
Storer, T., Glisson, W., Renaud, K.
core  

Feed radiation patterns modified by a dichroic plate

open access: yes, 1978
The 20 GHz copolar radiation patterns of a feed 4.25 cm from a flat dichroic plate 15 cm in diameter have been computed using a mode-matching technique.
Parker, Edward A., Langsford, P.A.
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Dietary patterns and adult asthma: population-based case-control study.

open access: yes, 2010
BACKGROUND: Epidemiological studies of diet and asthma have focused on relations with intakes of individual nutrients and foods and evidence has been conflicting. Few studies have examined associations with dietary patterns.
Thompson, R L   +6 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Design Pattern Detection by Using Meta Patterns [PDF]

open access: yes, 2008
One of the approaches to improve program understanding is to extract what kinds of design pattern are used in existing object-oriented software. This paper proposes a technique for efficiently and accurately detecting occurrences of design patterns ...
KOBAYASHI, Takashi   +4 more
core  

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