Results 161 to 170 of about 14,943,986 (252)

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Does the breathing response limit exercise tolerance in patients weaning from mechanical ventilation? [PDF]

ERJ Open Res
Nijhoff T, Zoethout S, Klooster E, Oosterwegel A, Millen X, Kök M, van der Sleen BJ, Greven T, Langeveld B, van den Oever HLA.   +9 more
europepmc   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Deep learning-based spatial immunoprofiling of multiplex immunofluorescence images distinguishes tuberculosis disease states in diversity outbred mice. [PDF]

PLoS One
Sajjad U, Crossland NA, Gurcan MN, Beamer G, Niazi MKK.   +4 more
europepmc   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Evaluating the Impact of Outcome Delay on the Efficiency of Sample Size Re-Estimation. [PDF]

Pharm Stat
Mukherjee A, Grayling MJ, Wason JMS.
europepmc   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Spatially-resolved single-cell imaging of melanoma brain metastases identifies localized immune patterns predictive of immune checkpoint blockade response. [PDF]

Neuro Oncol
Voglis S, Schulz D, Eling N, De Souza N, Regli L, Neidert MC, Czabanka M, Weller M, Le Rhun E, Mihic-Probst D, Levesque M, Bodenmiller B.   +11 more
europepmc   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Beyond Shedding: Conserved Retention of ZAN After the Acrosome Reaction Across Rabbit, Boar, and Bull Sperm. [PDF]

Int J Mol Sci
Hernández-Falcó M, Díaz-Fuster L, Ferrer-Cortés N, Robles-Gómez L, Sáez-Espinosa P, Gómez-Torres MJ.   +5 more
europepmc   +1 more source