Results 31 to 40 of about 11,150,918 (224)

Pasta, a Versatile Transcriptomic Clock, Maps the Chemical and Genetic Determinants of Aging and Rejuvenation

Advanced Science, EarlyView.
Pasta is a transcriptomic aging clock built on an age‐shift learning framework and trained on 17 000 samples across 21 datasets. It accurately predicts relative biological age across tissues, platforms, and species, captures stemness‐to‐senescence transitions, and identifies age‐modulatory perturbations.
Jérôme Salignon, Maria Tsiokou, Patricia Marqués, Enriqueta Rodríguez‐Diaz, Hazel Ang, Federico Pietrocola, Christian G. Riedel   +6 more
wiley   +1 more source

m6A‐Driven Pexophagy Triggers Placental Ferroptosis to Impair Fetal Growth Upon Environmental Stress

Advanced Science, EarlyView.
Prenatal environmental stress exposure promotes m6A modification to drive PEX2‐dependent pexophagy, thereby causing placental ferroptosis and FGR. ABSTRACT The role and underlying mechanisms of placental ferroptosis in fetal growth restriction (FGR) induced by environmental stress remain poorly understood.
Xin‐Xin Zhang, Ye‐Xin Luo, Cheng‐Fang Sun, Rui Pan, Yu‐Xi Wu, Zhi Yuan, Xin‐Run Wang, Xu‐Dong Zhang, Lan‐Lan Wu, Xiang‐Yu Yao, Zhan‐Dong Song, Wei Chang, Tian Wei, Pan‐Yuan Cai, Tian‐Ci Zhang, Yong‐Wei Xiong, De‐Xiang Xu, Hua Wang, Hua‐Long Zhu   +18 more
wiley   +1 more source

Hysteroscopic metroplasty for T-shaped uterus: A Systematic Review and Meta-analysis of Reproductive Outcomes

, 2020
Importance: To date, a comprehensive review on the safety and effectiveness of hysteroscopic metroplasty for T-shaped uterus is still missing. Objective: To provide a robust synthesis of the available studies investigating reproductive outcomes after ...
Andrisani A., Alonso Pacheco L, Di Spiezio Sardo A, Raffaelli R., Vitale Salvatore Giovanni, Laganà AS, Alonso Pacheco, Luis, Casarin J, Lagana A. S., Brunella Zizolfi, Casarin J., Pacheco L. A., Zizolfi B., Massimo Franchi, Haimovich S, Vitale S. G., Andrisani, Alessandra, Carugno, Jose, Salvatore Giovanni Vitale, Jvan Casarin, Antonio Simone Laganà, Laganà, Antonio Simone, Amerigo Vitagliano, Jose Carugno, Carugno J, Garzon S, Vitagliano A., Fabio Ghezzi, Di Spiezio Sardo, Attilio, Cromi, Antonella, Antonella Cromi, Attilio Di Spiezio Sardo, Luis Alonso Pacheco, Alessandra Andrisani, Haimovich S., Raffaelli R, Raffaelli, Ricciarda, Sergio Haimovich, Franchi M, Garzon S., Zizolfi, Brunella, Ghezzi F, Andrisani A, Simone Garzon, Franchi, Massimo, Ricciarda Raffaelli, Cromi A., Ghezzi F., Zizolfi B, Cromi A, Haimovich, Sergio, Vitale, Salvatore Giovanni, Di Spiezio Sardo A., Casarin, Jvan, Franchi M., Vitagliano, Amerigo, Carugno J., Garzon, Simone, Ghezzi, Fabio, Vitagliano A   +59 more
core   +1 more source

Lactobacillus‐Loaded Bioadhesive Hydrogel with Prolonged Retention and Microenvironmental Remodeling for Endometrial Repair and Fertility Restoration

Advanced Science, EarlyView.
A bioactive adhesive hydrogel capable of long‐term uterine retention (>14 days) and local microenvironment modulation is developed by straightforward integration of α‐lipoic acid, L‐arginine, tannic acid, and Lactobacillus johnsonii, which can markedly enhance endometrial repair and restore fertility in a rat model of endometrial injury.
Lifa Chen, Hui Zhou, Yifei Li, Yi Liang, Yifan Zhang, Huiyu Huang, Qiuxian Xie, Youchen Tang, Huixia Ye, Yu Zhang   +9 more
wiley   +1 more source

Modern hysteroscopic management of congenital uterine anomalies: current techniques, emerging technologies, and future directions

Frontiers in Surgery
BackgroundCongenital uterine anomalies are clinically relevant in reproductive medicine, particularly among women with infertility, recurrent pregnancy loss, adverse obstetric outcomes, or obstructive symptoms. Hysteroscopy has transformed the management
Mariana da Cunha Vieira, Giovanna C. C. Martin, Katherine A. R. Miller, Juliana A. Oliveira, Ana Clara P. Servidoni, Ana Clara P. Servidoni, Mauricio S. Abrao, Mauricio S. Abrao   +7 more
doaj   +1 more source

AL398, A Novel NSUN6 Inhibitor, Attenuates Epithelial‐Mesenchymal Transition and Metastasis in Endometrial Cancer by Abrogating m5C‐Dependent Stabilization of Snail mRNA

Advanced Science, EarlyView.
Proposed molecular mechanism: NSUN6 catalyzes m5C methylation on Snail mRNA to enhance its stability, leading to Snail upregulation and EMT promotion. The first‐in‐class inhibitor AL398 suppresses endometrial cancer metastasis by targeting the NSUN6‐m5C‐Snail. axis. ABSTRACT Endometrial cancer (EC) constitutes a leading gynecologic malignancy for which
Xiangzhuan Zhao, Linlin Yang, Huanxiang Chen, Chenfeng Guo, Hongshen Lu, Ying Zhu, Xuanzhi Wang, Yang Li, Ruike Zhang, Zichong Huang, Yifang Chen, Keyu Jin, Zeduo Xu, Lingxiu Meng, Longfeng Zhang, Yuanyuan Han, Yicong Yan, Qiaozhen Kang, Junhu Wan, Hongyang Liu   +19 more
wiley   +1 more source

An Injectable ROS‐Responsive Nanozyme Hydrogel Regulates the Uterine Microenvironment to Prevent Intrauterine Adhesions

Advanced Science, EarlyView.
The injectable CeTA@GPP hydrogel is administered via intrauterine injection, forming a protective barrier. In the high ROS inflammatory microenvironment of injured endometrium, boronate ester cleavage triggers responsive CeTA release and local enrichment.
Peixian Cheng, Jian Song, Yuxin Li, Ming Chen, Zeshen Liang, Binyao Qiu, Xuemin Liu, Xuetao Shi, Yong Fan   +8 more
wiley   +1 more source

Prevalence of dysmorphic uterus in infertile women by 3D-TVUS: a retrospective longitudinal cohort study

Reproductive Biology and Endocrinology
Background The true prevalence and clinical significance of congenital uterine malformations (CUM), particularly the dysmorphic uterus, in infertile populations remain a matter of debate, largely due to historical limitations in diagnostic methods.
Patsama Vichinsartvichai, Sappawit Lertlerphant, Sarwinee Ratchanon   +2 more
doaj   +1 more source

Tumor Exposomics: A New Paradigm for Individualized Continuous Exposure Monitoring

Advanced Science, EarlyView.
Tumor exposomics integrates continuous monitoring of environmental exposures, endogenous biological responses, and behavioral factors within a unified temporal framework. By combining multimodal sensing technologies with AI‐enabled causal modeling, this emerging paradigm reconstructs exposure‐damage trajectories and supports individualized dynamic risk
Kaicheng Shen, Weiyi Wang, Yang Wang, Yiqiang Wu, Xiaohong Liu, Wei Zhang, Juanjuan Ou   +6 more
wiley   +1 more source

Surgical Technique of Deceased Donor in Uterus Transplantation

, 2019
The use of a deceased donor for procurement of a uterus offers several advantages over live donor. The dissection of the vascular supply to the uterus can be accomplished at a level that provides adequate length and diameter.
Tzakis, A., Andreas Tzakis, Michael Olausson, Olausson, Michael,, Tommaso Falcone, Falcone, T.   +5 more
core   +1 more source